Art

J-GLOBAL ID：200902101075834732   Reference number：99A0519654

Hyaluronic Acid Suppresses the Reduction of α2(VI) Collagen Gene Expression Caused by Interleukin-1β in Cultured Rabbit Articular Chondrocytes.

ヒアルロン酸は培養ウサギ関節軟骨でインターロイキン-1βによるα2(VI)コラーゲン遺伝子発現の減少を抑制する

Author (4)： GOTO H (Iwate Medical Univ., Morioka) ,  ONODERA T (Iwate Medical Univ., Morioka) ,  HIRANO H (Iwate Medical Univ., Morioka) ,  SHIMAMURA T (Iwate Medical Univ., Morioka)
Material： Tohoku Journal of Experimental Medicine  (Tohoku J Exp Med)
Volume： 187  Issue： 1  Page： 1-13  Publication year： Jan. 1999 
JST Material Number： G0649A  ISSN： 0040-8727  CODEN： TJEMAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *hyaluronic acid ,...
Semi thesaurus term： hare ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=99A0519654&from=J-GLOBAL&jstjournalNo=G0649A") }}

JST classification (3)： Biological function  (EB02020R) ,  Gene expression  (EC02040Q) ,  Cytokines  (EB08090G)

Reference (23)：

• Aibe, K., Ryu, J. & Sano, S. (1996) Effects of hyaluronic acid on cartilage metabolism in free chondrocytes. <i>Journal of Orthopaedic Science</i>, <b>1</b>, 268-276.
• Arend, W.P. & Dayer, J.M. (1995) Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. <i>Arthritis Rheum</i>., <b>38</b>, 151-160.
• Bathon, J.M., Hwang, J.J., Shin, L.H., Precht, P.A., Towns, M.C. & Horton, W.J. (1994) Type VI collagen-specific messenger RNA is expressed constitutively by cultured human synovial fibroblasts and is suppressed by interleukin-1. <i>Arthritis Rheum</i>., <b>37</b>, 1350-1356.
• Chandrasekhar, S., Harvey, A.K., Higginbotham, J.D. & Horton, W.E. (1990) Interleukin-1-induced suppression of type II collagen gene transcription involves DNA regulatory elements. <i>Exp. Cell Res</i>., <b>191</b>, 105-114.
• Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. <i>Anal. Biochem</i>., <b>162</b>, 156-159.

Terms in the title (7)： ヒアルロン酸 ,  培養 ,  ウサギ ,  関節軟骨 ,  インターロイキン-1β ,  コラーゲン ,  遺伝子発現