Art

J-GLOBAL ID：200902101414975103   Reference number：94A0959051

Selective κ-Opioid Agonists: Synthesis and Structure-Activity Relationships of Piperidines Incorporating an Oxo-Containing Acyl Group.

選択的κ-オピオイドアゴニスト オキソ-含有アシル基を有するピペリジンの合成と構造-活性相関

Author (6)： GIARDINA G (Smith Kline Beecham Farmaceutici S.p.A., Milan, ITA) ,  CLARKE G D (Smith Kline Beecham Farmaceutici S.p.A., Milan, ITA) ,  DONDIO G (Smith Kline Beecham Farmaceutici S.p.A., Milan, ITA) ,  PETRONE G (Smith Kline Beecham Farmaceutici S.p.A., Milan, ITA) ,  SBACCHI M (Smith Kline Beecham Farmaceutici S.p.A., Milan, ITA) ,  VECCHIETTI V (Smith Kline Beecham Farmaceutici S.p.A., Milan, ITA)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 37  Issue： 21  Page： 3482-3491  Publication year： Oct. 14, 1994 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： carboxamide ,...
Semi thesaurus term： piperidines ,...

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JST classification (2)： Basic research of addictive analgesics and narcotics  (GW03080Z) ,  Pyridines  (CF07095Q)

Substance index (17)： 1-[2α-(Pyrrolizinomethyl)piperidino]-2-(tetralin-6-yl)ethanone ,  1-[2α-(Pyrrolizinomethyl)piperidino]-2-(1-oxoindan-5-yl)ethanone ,  1-[2α-(Pyrrolizinomethyl)piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-(Pyrrolizinomethyl)piperidino]-2-[(5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten)-2-yl]ethanone ,  1-[2α-(Pyrrolizinomethyl)piperidino]-2-(4-oxotetralin-6-yl)ethanone ,  BRL-53001 ,  1-[2α-[(Ethylmethylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(Diethylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(Propylmethylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(Isopropylmethylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(tert-Butylmethylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(Allylmethylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(2-Propynylmethylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(Methylcyclopropylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[[(Cyclopropylmethyl)methylamino]methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(Methylcyclobutylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone ,  1-[2α-[(Methylcyclopentylamino)methyl]piperidino]-2-(1-oxotetralin-6-yl)ethanone

Terms in the title (3)： アシル基 ,  ピペリジン ,  構造-活性相関