Art

J-GLOBAL ID：200902102871750946   Reference number：93A0668326

R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. I. Taxonomy, fermentation, isolation and biological properties.

R1128物質,Streptomyces生産の新規非ステロイド系エストローゲン受容体きっ抗剤 I 分類,発酵,単離と生物学的特性

Author (6)： HORI Y (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  ABE Y (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  EZAKI M (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  GOTO T (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  OKUHARA M (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  KOHSAKA M (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 46  Issue： 7  Page： 1055-1062  Publication year： Jul. 1993 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antineoplastic antibiotics ,...
Semi thesaurus term： Streptomyces ,...

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JST classification (1)： Antibiotics in general  (GX01000E)

Substance index (4)： R-1128A ,  R-1128B ,  R-1128C ,  R-1128D

Reference (19)：

• 1) LITHERLAND, S. & I. M. JACKSON: Antiestrogcns in the management of hormone-dependent breast cancer. Cancer Treat. Rev. 15: 183-194, 1988
• 2) HORI, Y.; S. TAKASE, N. SHIGEMATSU, T. GOTO, M. OKUHARA & M. KOHSAKA: R1128 substances, novel nonsteroidal estrogen-receptor antagonists produced by a Streptomyces. II. Physico-chemical properties and structure determination. J. Antibiotics 46: 1063-1068, 1993
• 3) HORI, Y.; Y. ABE, M. NISHIMURA, T. GOTO, M. OKUHARA & M. KOHSAKA: R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. III. Pharmacological properties and antitumor activities. J. Antibiotics 46: 1069-1075, 1993
• 4) SKIRLING, E. B. & D. GOTTLIEB: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313-340, 1966
• 5) WAKSMAN, S. A. (Ed.): The Actinomycetes. Vol. 2. Classification, Identification and Description of Genera and Species. Williams & Wilkins Co., Baltimore, 1961

Terms in the title (9)： 物質 ,  Streptomyces ,  ステロイド ,  受容体 ,  きっ抗剤 ,  分類 ,  発酵 ,  単離 ,  生物学的特性