A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21<sup>Waf1/Cip1/Sdi1</sup> expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2.

OKAICHI K; WANG L-H; SASAKI J; SAYA H; TADA M; OKUMURA Y

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J-GLOBAL ID：200902103347028555 Reference number：00A0086328

A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21^{Waf1/Cip1/Sdi1} expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2.

酵母機能アッセイにより突然変異として検出されなかったヒトp53の点突然変異は、ヒト骨肉腫細胞系Saos-2におけるイオン照射に応答してアポトーシスを生じるが、p21^{Waf1/Cip1/Sdi1}発現は生じない

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Volume： 45 Issue： 4 Page： 975-979 Publication year： Nov. 01, 1999
JST Material Number： B0262B ISSN： 0360-3016 Document type： Article
Country of issue： Netherlands (NLD) Language： ENGLISH (EN)

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A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2.

A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21^{Waf1/Cip1/Sdi1} expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2.