Art

J-GLOBAL ID：200902103949384484   Reference number：96A0902682

Dihydropyrazine Derivatives as a New Type of DNA Strand Breaking Agent.

新規DNA鎖分断薬としてのジヒドロピラジン誘導体

Author (5)： YAMAGUCHI T (Miyazaki Medical Coll., Miyazaki, JPN) ,  KASHIGE N (Fukuoka Univ., Fukuoka, JPN) ,  MISHIRO N (Miyazaki Medical Coll., Miyazaki, JPN) ,  MIAKE F (Fukuoka Univ., Fukuoka, JPN) ,  WATANABE K (Fukuoka Univ., Fukuoka, JPN)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 19  Issue： 10  Page： 1261-1265  Publication year： Oct. 1996 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： genetic toxicity ,...
Semi thesaurus term： hydropyrazines

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JST classification (1)： Structure-activity relationship of drugs  (GV01050B)

Substance index (7)： 4,4′-[(2,5-Dihydropyrazine)-2,5-diyl]bis[(2R,3R,4R)-butane-1,2,3,4-tetrol] ,  2,5-Dihydro-3,6-dimethylpyrazine ,  DHDMP ,  DHP-2 ,  HTMP ,  rel-2,3-Dimethyl-4aβ^*,5,6,7,8,8aα^*-hexahydroquinoxaline ,  2,3-Dimethyl-4aα,5,6,7,8,8aα-hexahydroquinoxaline

Reference (17)：

• KASHIGE, N. Biol. Pharm. Bull. 1995, 18, 653-658
• MAGAS, J. S. J. Agric. Food Chem. 1973, 21, 22-30
• ISHIGURO, T. Yakugaku Zasshi. 1958, 78, 229-231
• BEAK, P. J. Am. Chem. Soc. 1967, 89, 2375-2385
• ARNOLD, D. R. Can. J. Chem. 1970, 49, 923-935

Terms in the title (3)： DNA ,  分断 ,  ジヒドロピラジン誘導体