Art

J-GLOBAL ID：200902107216403402   Reference number：01A0016931

[2-(ω-Phenylalkyl)phenoxy]alkylamines. III. Synthesis and Selective Serotonin-2 Receptor Binding. (2).

[2-(ω-フェニルアルキル)フェノキシ]アルキルアミン類 III 合成及び選択的セロトニン-2受容体結合 2

Author (8)： TANAKA N (Sankyo Co. Ltd., Tokyo, JPN) ,  GOTO R (Sankyo Co. Ltd., Tokyo, JPN) ,  ITO R (Sankyo Co. Ltd., Tokyo, JPN) ,  HAYAKAWA M (Sankyo Co. Ltd., Tokyo, JPN) ,  SUGIDACHI A (Sankyo Co. Ltd., Tokyo, JPN) ,  OGAWA T (Sankyo Co. Ltd., Tokyo, JPN) ,  ASAI F (Sankyo Co. Ltd., Tokyo, JPN) ,  FUJIMOTO K (Sankyo Co. Ltd., Tokyo, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 48  Issue： 11  Page： 1729-1739  Publication year： Nov. 01, 2000 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...

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JST classification (2)： Pyrroles  (CF07076L) ,  Synthesis of drugs  (GV01030F)

Substance index (33)： (4R)-1-(tert-Butoxycarbonyl)-4β-(benzyloxy)-L-proline ,  (2R)-2α-[2-(Tosyloxy)ethyl]-4β-(benzyloxy)-1-pyrrolidinecarboxylic acid ethyl ester ,  trans-N-Boc-4-Hydroxy-L-proline ,  (2S)-2β-[2-(Tosyloxy)ethyl]-4β-(benzyloxy)-1-pyrrolidinecarboxylic acid ethyl ester ,  (2R)-1-Methyl-2α-[2-(2-phenethylphenoxy)ethyl]pyrrolidine-4β-ol ,  (2R)-1-Methyl-2α-[2-[2-(2-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-ol ,  2-[2-[(2R)-1-Methyl-4β-hydroxypyrrolidine-2-yl]ethoxy]-3′-methoxybibenzyl ,  (2R)-1-Methyl-2α-[2-[2-(4-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-ol ,  (2R)-1-Methyl-2α-[2-[2-(3,5-dimethoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-ol ,  (2R)-1-Methyl-2α-[2-[2-(3-hydroxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-ol ,  2-[2-[(2R)-1-Methyl-4α-hydroxypyrrolidine-2-yl]ethoxy]-3′-methoxybibenzyl ,  (2S)-1-Methyl-2β-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-ol ,  2-[2-[(2S)-1-Methyl-4α-hydroxypyrrolidine-2-yl]ethoxy]-3′-methoxybibenzyl ,  Ketanserin ,  Sarpogrelate ,  M-1 ,  (2S)-1-Methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine ,  (2R)-1-Methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4-one ,  (2S)-1-Methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4-one (Z)-oxime ,  (2S)-1-Methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4-one (E)-oxime ,  (2S)-1-Methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-amine ,  N-Phenylcarbamic acid (2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  Succinic acid hydrogen 1-[(2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl] ester ,  Carbonic acid ethyl(2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  Carbonic acid phenyl(2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  Benzoic acid (2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  Acetic acid (2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  Hexanoic acid (2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  Heptanoic acid (2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  Octanoic acid (2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  Decanoic acid (2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester ,  R-102444 ,  Palmitic acid (2R)-1-methyl-2α-[2-[2-(3-methoxyphenethyl)phenoxy]ethyl]pyrrolidine-4β-yl ester

Reference (32)：

• ROSS, R. N.Engl.J.Med. 1986, 314, 488-500
• DeCLERCK, F. Fed.Proc. 1983, 42, 228-232
• MALLARKEY, G. Br.J.Pharmacol. 1985, 84, 425-430
• PANAK, E. Haemostasis. 1983, 13, 1-54
• WHITE, J. G. Scand.J.Haematol. 1970, 7, 145-151

Terms in the title (3)： アルキルアミン ,  セロトニン ,  受容体結合