Art

J-GLOBAL ID：200902107478312548   Reference number：94A0314526

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.

FR901228,Chromobacterium violaceum No.968生産新規抗腫よう二環性デプシペプチド 3 担癌マウスでの抗腫よう活性

Author (7)： UEDA H (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  MANDA T (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  MATSUMOTO S (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  MUKUMOTO S (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  NISHIGAKI F (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  KAWAMURA I (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  SHIMOMURA K (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 47  Issue： 3  Page： 315-323  Publication year： Mar. 1994 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antibiotic producing microorganism ,...
Semi thesaurus term： Chromobacterium ,...

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JST classification (1)： Basic research of antitumor(=antineoplastic)antibiotics  (GX05040Y)

Substance index (1)： Romidepsin

Reference (14)：

• 1) DENNY, W. A.: New directions in the design and evaluation of anti-cancer drugs. Drug Design and Delivery 3: 99-124, 1988
• 2) BOS, J. L.: The ras gene family and human carcinogenesis. Mutat. Res. 195: 255-271, 1988
• 3) UEDA, H.; H. NAKAJIMA, Y. HORI, T. FUJITA, M. NISHIMURA, T. GOTO & M. OKUHARA: FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J. Antibiotics 47: 301-310, 1994
• 4) SHIGEMATSU, N.; H. UEDA, S. TAKASE, H. TANAKA, K. YAMAMOTO & T. TADA: FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination. J. Antibiotics 47:311-314,1994
• 5) UEDA, H.; H. NAKAJIMA, Y. HORI, T. GOTO & M. OKUHARA: Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968, on Ha-ras transformed NIH3T3 cells. Biosci. Biotech. Biochem., to submitted

Terms in the title (7)： Chromobacterium ,  NO ,  腫よう ,  二環性 ,  デプシペプチド ,  担癌マウス ,  抗腫よう活性