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J-GLOBAL ID：200902107769165747   Reference number：96A0863000

Pyrrolosporin A, a New Antitumor Antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, Physico-chemical Properties, Spectroscopic Study and X-ray Analysis.

Micromonospora sp.C39217-R109-7生産の新抗腫よう抗生物質ピロロスポリンA 2 その単離,物理化学性状,スペクトル研究とX線解析

Author (7)： SCHROEDER D R (Bristol-Myers Squibb Pharmaceutical Res. Inst., Connecticut, USA) ,  COLSON K L (Bristol-Myers Squibb Pharmaceutical Res. Inst., Connecticut, USA) ,  KLOHR S E (Bristol-Myers Squibb Pharmaceutical Res. Inst., Connecticut, USA) ,  LEE M S (Bristol-Myers Squibb Pharmaceutical Res. Inst., Connecticut, USA) ,  MATSON J A (Bristol-Myers Squibb Pharmaceutical Res. Inst., Connecticut, USA) ,  BRINEN L S (Cornell Univ., New York, USA) ,  CLARDY J (Cornell Univ., New York, USA)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 49  Issue： 9  Page： 865-872  Publication year： Sep. 1996 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antibiotics fermentation ,...
Semi thesaurus term： Micromonospora ,...

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JST classification (1)： Antibiotic fermentation  (GX03000S)

Substance index (1)： Pyrrolosporin A

Reference (11)：

• 1) SCHROEDER, D. R.; K. S. LAM, G. A. HESLER, D. R. GUSTAVSON, K. TOMITA & R. L. BERRY: Antitumor antibiotic BMY-42448. U.S. Patent No. 5,082,933 issued January 21,1992. Pyrrolosporin A was previously referred to as BMY-42448
• 2) LAM, K. S.; G. A. HESLER, D. R. GUSTAVSON, R. L. BERRY, K. TOMITA, J. L. MACBETH & S. FORENZA: Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7.1. Taxonomy of the producing organism, fermentation and biological activity. J. Antibiotics 49: 860-864, 1996
• 3) GELIN, S. & P. POLLET: Tautomerism in acyl tetronic acids. Tetrahedron Lett. 21: 4491 -4494, 1980
• 4) MALLAMS, A. K.; M. S. PUAR & R. R. ROSSMAN: Kijammicin. Part 3. Structure and absolute stereochemistry of kijanimicin. J. Chem. Soc. Perkin Trans. I 1983: 1497-1534, 1983
• 5) HIRAYAMA, N.; M. KASAI, K. SHIRAHATO, Y. OHASHI & Y. SASADA: The structure of tetronolide, the aglycone of antitumor antibiotic tetrocarcin. Tetrahedron Lett. 21: 2559-2560, 1980

Terms in the title (7)： Micromonospora ,  抗腫よう抗生物質 ,  単離 ,  物理化学性状 ,  スペクトル ,  研究 ,  X線解析