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J-GLOBAL ID：200902108308261163   Reference number：96A0930058

The Shurosporine Producing Strain Streptomyces longisporoflavus Produces Metabolites Related to K-252a. Proposal for Biosynthetic Intermediates of K-252a.

スタウロスポリン生産Streptomyces longisporoflavus株はK-252a関連代謝産物を生産する K-252aの生合成中間体に関する提案

Author (4)： CAI Y (CIBA-GEIGY Ltd., Basel, CHE) ,  FREDENHAGEN A (CIBA-GEIGY Ltd., Basel, CHE) ,  HUG P (CIBA-GEIGY Ltd., Basel, CHE) ,  PETER H H (CIBA-GEIGY Ltd., Basel, CHE)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 49  Issue： 10  Page： 1060-1062  Publication year： Oct. 1996 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antibiotics fermentation ,...
Semi thesaurus term： Streptomyces ,...

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JST classification (2)： Antibiotic fermentation  (GX03000S) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (6)： K-252a ,  K-252c ,  TAN-1030A ,  Staurosporine ,  N-Methylstaurosporine ,  (9S)-2,3,9,10,11,12-Hexahydro-10α-(methylamino)-9-methyl-1-oxo-9β,12β-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

Reference (15)：

• 1) OMURA, S.; Y. IWAI, A. HIRANO, A. NAKAGAWA, J. AWAYA, H. TSUCHIYA, Y. TAKAHASHI & R. MASUMAI A new alkaloid AM-2282 of Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization. J. Antibiotics 30: 275-282, 1977
• 2) TAMAOKI, T.; H. NOMOTO, I. TAKAHASHI, Y. KATO, M. MORIMOTO & F. TOMITA: Staurosporine, a potent inhibitor of phospholipid/calcium dependent protein kinase. Biochem. Biophys. Res. Commun. 135: 397-402, 1986
• 3) TANIDA, S.; M. TAKIZAWA, T. TAKAHASHI, S. TSUBOTANI & S. HARADA: TAN-999 and TAN-1030A, new indolocarbazole alkaloids with macrophage-activating properties. J. Antibiotics 42: 1619-1630, 1989
• 4) TAKAHASHI, I.; K. ASANO, I. KAWAMOTO, T. TAMAOKI & H. NAKANO: UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J. Antibiotics 42: 564-570, 1989
• 5) OSADA, H.; H. TAKAHASHI, K. TSUNODA, H. KUSAKABE & K. ISONO: A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). I. Screening, taxonomy, fermentation and biological activity. J. Antibiotics 43: 163-167, 1990

Terms in the title (7)： スタウロスポリン ,  Streptomyces ,  株 ,  K-252a ,  代謝産物 ,  生合成中間体 ,  提案