Art

J-GLOBAL ID：200902108349705203   Reference number：00A0970640

Synthesis and Biological Evaluation of Certain α,β-Unsaturated Ketones and Their Corresponding Fused Pyridines as Antiviral and Cytotoxic Agents.

α,β-不飽和ケトン類と関連縮合ピリジン類の合成ならびに抗ウイルス薬および細胞毒剤としての生物学的評価

Author (5)： EL-SUBBAGH H I (King Saud Univ., Riyadh, SAU) ,  ABU-ZAID S M (King Saud Univ., Riyadh, SAU) ,  MAHRAN M A (King Saud Univ., Riyadh, SAU) ,  BADRIA F A (Mansoura Univ., Mansoura, EGY) ,  AL-OBAID A M (King Saud Univ., Riyadh, SAU)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 43  Issue： 15  Page： 2915-2921  Publication year： Jul. 27, 2000 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...
Semi thesaurus term： herpes simplex virus 1 ,...

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JST classification (3)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of antiviral drugs  (GW17040O) ,  Other condensed derivatives of pyridine  (CF07097Y)

Substance index (19)： 1-Methyl-3,5-bis[(E)-4-chlorobenzylidene]piperidine-4-one ,  1-Methyl-3,5-bis[(E)-4-pyridylmethylene]piperidine-4-one ,  (3E,5E)-1-Methyl-3,5-bis(2-thienylmethylene)piperidine-4-one ,  1-Methyl-3,5-bis[(E)-4-methylbenzylidene]piperidine-4-ol ,  1-Methyl-3,5-bis[(E)-4-methoxybenzylidene]piperidine-4-ol ,  (3E,5E)-1-Methyl-3,5-bis(2-thienylmethylene)piperidine-4-ol ,  (7E)-2,5-Dimethyl-3-(2-thienyl)-7-(2-thienylmethylene)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridine ,  2-Phenyl-3-(4-methylphenyl)-5-methyl-7-[(E)-4-methylbenzylidene]-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridine ,  2-Phenyl-3-(4-methoxyphenyl)-5-methyl-7-[(E)-4-methoxybenzylidene]-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridine ,  (7E)-2-Phenyl-3-(2-thienyl)-5-methyl-7-(2-thienylmethylene)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridine ,  4-(4-Methylphenyl)-6-methyl-8-[(E)-4-methylbenzylidene]-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine-2(1H)-thione ,  4-(4-Methoxyphenyl)-6-methyl-8-[(E)-4-methoxybenzylidene]-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine-2(1H)-thione ,  (8E)-4-(2-Thienyl)-6-methyl-8-(2-thienylmethylene)-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine-2(1H)-thione ,  2-Oxo-4-(4-methylphenyl)-6-methyl-8-[(E)-4-methylbenzylidene]-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile ,  2-Oxo-4-(4-methoxyphenyl)-6-methyl-8-[(E)-4-methoxybenzylidene]-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile ,  (8E)-2-Oxo-4-(2-thienyl)-6-methyl-8-(2-thienylmethylene)-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile ,  2-Amino-4-(4-methylphenyl)-6-methyl-8-[(E)-4-methylbenzylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile ,  2-Amino-4-(4-methoxyphenyl)-6-methyl-8-[(E)-4-methoxybenzylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile ,  (8E)-2-Amino-4-(2-thienyl)-6-methyl-8-(2-thienylmethylene)-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile

Terms in the title (6)： 不飽和ケトン類 ,  縮合 ,  ピリジン類 ,  抗ウイルス薬 ,  細胞毒 ,  生物学的評価