Art

J-GLOBAL ID：200902108518836410   Reference number：03A0181834

Kinetic Impact of Presystemic Intestinal Metabolism on Drug Absorption: Experiment and Data Analysis for the Prediction of In Vivo Absorption from In Vitro Data.

薬物吸収における前全身性の腸管代謝の速度論的影響 in vitroのデータからのin vivoの吸収の予測のための実験とデータ解析

Author (1)： MIZUMA T (Tokyo Univ., Tokyo, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 17  Issue： 6  Page： 496-506  Publication year： 2002 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *pharmacokinetics ,...
Semi thesaurus term： bridged compound ,...

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JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (8)： Phenacetin ,  Morphine ,  Naloxone ,  Buprenorphine ,  1-Naphthol ,  Fenoterol ,  Salicylamide ,  Altretamine

Reference (34)：

• ROWLAND, M. Clinical Pharmacokinetics. Concept and Applications. 1995, 14
• MIZUMA, T. Role of transporter and metabolic enzyme in intestinal drug absorption. Xenob. Metab. Disposit. 2000, 15, Suppl., S100-S101
• MIZUMA, T. Intestinal Na^+/glucose cotransporter-mediated transport of glucose conjugate formed from disaccharide conjugate. Biochim. Biophys. Acta. 1998, 1379, 1-6
• MIZUMA, T. Carrier-mediated oral drug delivery utilizing glucose transporter : importance of turnover rate of transporter in drug delivery. Presented at The Ninth Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Nagoya. 1998
• MIZUMA, T. Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenyl, acetaminophen and 1-naphthol : kinetic demonstration of the influence of glucuroidation metabolism on intestinal absorption in rats. Biochim. Biophys. Acta. 1998, 1425, 398-404

Terms in the title (8)： 薬物吸収 ,  全身 ,  腸管 ,  代謝 ,  速度論 ,  予測 ,  実験 ,  データ解析