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J-GLOBAL ID：200902109555353310   Reference number：95A0966159

Tyrosine Kinase Inhibitors. 7. 7-Amino-4-(phenylamino)- and 7-Amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: A New Class of Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor.

チロシンキナーゼ阻害薬 7 7-アミノ-4-(フェニルアミノ)-および7-アミノ-4-[(フェニルメチル)アミノ]ピリド[4,3-d]ピリミジン類 上皮成長因子受容体のチロシンキナーゼ活性に対する新しい阻害薬

Author (5)： THOMPSON A M (Univ. Auckland School of Medicine, Auckland, NZL) ,  BRIDGES A J (Parke-Davis Pharmaceutical Res., Michigan) ,  FRY D W (Parke-Davis Pharmaceutical Res., Michigan) ,  KRAKER A J (Parke-Davis Pharmaceutical Res., Michigan) ,  DENNY W A (Univ. Auckland School of Medicine, Auckland, NZL)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 38  Issue： 19  Page： 3780-3788  Publication year： Sep. 15, 1995 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： enzyme inhibitor ,...

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JST classification (1)： Structure-activity relationship of drugs  (GV01050B)

Substance index (42)： N-(Phenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Nitrophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Nitrophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Nitrophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Bromophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  PD-153717 ,  N-(4-Bromophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Trifluoromethylphenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Trifluoromethylphenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Trifluoromethylphenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Methoxyphenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Methoxyphenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Methoxyphenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Aminophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Aminophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Aminophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Dimethylaminophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Dimethylaminophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  PD-69896 ,  N-(2-Nitrobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Nitrobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Nitrobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Bromobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Bromobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Bromobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Trifluoromethylbenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Trifluoromethylbenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Trifluoromethylbenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Methoxybenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Methoxybenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Methoxybenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Aminobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Aminobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Aminobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(2-Dimethylaminobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Dimethylaminobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(4-Dimethylaminobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Fluorophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  N-(3-Chlorophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine ,  3-[(7-Aminopyrido[4,3-d]pyrimidin-4-yl)amino]phenol ,  N-[3-[(7-Aminopyrido[4,3-d]pyrimidin-4-yl)amino]phenyl]acetamide ,  N-(3-Iodophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine

Terms in the title (6)： チロシンキナーゼ阻害薬 ,  ピリミジン類 ,  上皮成長因子受容体 ,  チロシンキナーゼ ,  活性 ,  阻害薬