Art

J-GLOBAL ID：200902111060737868   Reference number：94A0013069

New 4-Amino-7,8-dimethoxy-5H-pyrimido[5,4-b]indole Derivatives: Synthesis and Studies as Inhibitors of Phosphodiesterases.

新しい4-アミノ-7,8-ジメトキシ-5H-ピリミド[5,4-b]インドール誘導体 合成およびホスホジエステラーゼ阻害作用

Author (9)： MONGE A (Univ. Navarre, Pamplona, ESP) ,  MARTINEZ-CRESPO F J (Univ. Navarre, Pamplona, ESP) ,  VILLANUEVA M A (Univ. Navarre, Pamplona, ESP) ,  FONT M (Univ. Navarre, Pamplona, ESP) ,  SANTIAGO E (Univ. Navarre, Pamplona, ESP) ,  DE IRUJO J J M (Univ. Navarre, Pamplona, ESP) ,  ALBERDI E (Univ. Navarre, Pamplona, ESP) ,  JOSE LOPEZ-UNZU M (Univ. Navarre, Pamplona, ESP) ,  FRECHILLA D (Univ. Navarre, Pamplona, ESP)
Material： Archiv der Pharmazie  (Arch Pharm)
Volume： 326  Issue： 11  Page： 879-885  Publication year： Nov. 1993 
JST Material Number： A0451A  ISSN： 0365-6233  CODEN： ARPMAS  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： phosphodiesterase ,...
Semi thesaurus term： ピリミドインドール ,...

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JST classification (1)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (29)： 4-[4-Methylpiperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Piperonylpiperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Phenylpiperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[3-Methylphenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[3-(Trifluoromethyl)phenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[2,3-Dimethylphenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[2-Chlorophenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[4-Chlorophenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[4-Methoxyphenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[3-Methoxyphenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[4-Fluorophenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[3-Chlorophenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[2-Ethoxyphenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[3-Acetylphenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[2-Methoxyphenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[2-Hydroxyphenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-[4-Nitrophenyl]piperazino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[Anilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Chloroanilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Methoxyanilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Butylanilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Phenoxyanilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-(Acetylamino)anilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Hydroxyanilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Cyanoanilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Methylanilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-(Aminosulfonyl)anilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  4-[4-Benzoylanilino]-7,8-dimethoxy-5H-pyrimido[5,4-b]indole ,  7,8-Dimethoxy-5H-pyrimido[5,4-b]indol-4-amine

Terms in the title (3)： インドール誘導体 ,  ホスホジエステラーゼ ,  阻害作用