Art

J-GLOBAL ID：200902111514909790   Reference number：00A0889087

Changes in mRNA expression levels of synaptic- and target tissue-specific proteins after organophosphate exposure.

有機りん剤曝露によるシナプス及び標的組織の特異的蛋白質mRNA発現レベルの変化

Author (4)： MATSUDA H (Miyazaki Medical Coll., Miyazaki, JPN) ,  SEO Y (Miyazaki Medical Coll., Miyazaki, JPN) ,  KAKIZAKI E (Miyazaki Medical Coll., Miyazaki, JPN) ,  TAKAHAMA K (Miyazaki Medical Coll., Miyazaki, JPN)
Material： Legal Medicine  (Legal Med)
Volume： 2  Issue： 2  Page： 55-63  Publication year： Aug. 2000 
JST Material Number： L3645A  ISSN： 1344-6223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *organophosphorus compound ,...
Semi thesaurus term： *organophosphorus insecticide

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JST classification (2)： Toxicity of metals and metal compounds  (GZ02022V) ,  Gene expression  (EC02040Q)

Substance index (1)： Disulfoton

Reference (38)：

• CAVALIERE, MJ. Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds. Clin Toxicol. 1998, 36, 295-300
• PADILLA, S. Studies on the correlation between blood cholinesterase inhibition and target tissue inhibition in pesticide-treated rats. Toxicol. 1994, 92, 11-25
• KAUFER, D. Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission. Chem Biol Interact. 1999, 119, 20, 349-360
• KAUFER, D. Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature. 1998, 393, 373-376
• FRIEDMAN, A. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nature Med. 1996, 2, 1382-1385

Terms in the title (6)： 有機りん剤 ,  曝露 ,  シナプス ,  標的組織 ,  蛋白質 ,  mRNA発現