Art

J-GLOBAL ID：200902111848507685   Reference number：01A1036335

Asymmetric addition of nucleophiles to C-1 position of isoquinolines using (S)-alanine derivatives as chiral auxiliaries.

キラル補助化合物としての(S)-アラニン誘導体を使用するイソキノリン類のC1位への求核試薬不斉付加

Author (5)： ITOH T (Showa Univ., Tokyo, JPN) ,  NAGATA K (Showa Univ., Tokyo, JPN) ,  MIYAZAKI M (Showa Univ., Tokyo, JPN) ,  KAMEOKA K (Showa Univ., Tokyo, JPN) ,  OHSAWA A (Showa Univ., Tokyo, JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 57  Issue： 42  Page： 8827-8839  Publication year： Oct. 15, 2001 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： optical activity ,...
Semi thesaurus term： 不斉付加 ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=01A1036335&from=J-GLOBAL&jstjournalNo=E0234A") }}

JST classification (2)： Quinolines,isoquinolines  (CF07096H) ,  Synthesis of drugs  (GV01030F)

Substance index (47)： Alanine ,  Methylene chloride ,  Isoquinoline ,  4-Bromoisoquinoline ,  Ketene (benzyl)(trimethylsilyl)acetal ,  2-[2-(Phenylsulfonylamino)propionyl]-4-bromo-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[2-[(1-Naphthyl)sulfonylamino]propionyl]-4-bromo-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[2-[(4-Nitrophenyl)sulfonylamino]propionyl]-4-bromo-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[2-[(1,3-Dioxo-2H-isoindole-2-yl)sulfonylamino]propionyl]-4-bromo-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  5,8-Dibromoisoquinoline ,  Ketene phenyl(trimethylsilyl)acetal ,  α-(Trimethylsiloxy)styrene ,  2-(1,3-Dioxo-2H-isoindole-2-yl)propionyl chloride ,  2-(4-Nitrophenylsulfonylamino)propionyl chloride ,  Allyltributylstannane ,  2-[(2S)-2-[(1,3-Dioxo-2H-isoindole-2-yl)sulfonylamino]propionyl]-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[(2S)-2-[(4-Nitrophenyl)sulfonylamino]propionyl]-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[(2S)-2-[(1,3-Dioxo-2H-isoindole-2-yl)sulfonylamino]propionyl]-5,8-dibromo-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[(2S)-2-[(4-Nitrophenyl)sulfonylamino]propionyl]-5,8-dibromo-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[(2S)-2-[(1,3-Dioxo-2H-isoindole-2-yl)sulfonylamino]propionyl]-5,8-dibromo-1,2-dihydroisoquinoline-1-acetic acid phenyl ester ,  1-(2-Oxo-2-phenylethyl)-2-[(2S)-2-[(1,3-dioxo-2H-isoindole-2-yl)sulfonylamino]propionyl]-5,8-dibromo-1,2-dihydroisoquinoline ,  1-Allyl-2-[(2S)-2-(1,3-dioxo-2H-isoindole-2-yl)propionyl]-4-bromo-1,2-dihydroisoquinoline ,  1-Allyl-2-[(2S)-2-(1,3-dioxo-2H-isoindole-2-yl)propionyl]-1,2-dihydroisoquinoline ,  1-Allyl-2-[(2S)-2-(1,3-dioxo-2H-isoindole-2-yl)propionyl]-5,8-dibromo-1,2-dihydroisoquinoline ,  2-[(2S)-2-(1,3-Dioxo-2H-isoindole-2-yl)propionyl]-1,2,3,4-tetrahydroisoquinoline-1-acetic acid methyl ester ,  2-[(1S)-1-Methyl-2-(1-propyl-1,2,3,4-tetrahydroisoquinoline-2-yl)-2-oxoethyl]-2H-isoindole-1,3-dione ,  2-[(1S)-1-Methyl-2-(1-phenethyl-1,2,3,4-tetrahydroisoquinoline-2-yl)-2-oxoethyl]-2H-isoindole-1,3-dione ,  2-[(2S)-2-[(4-Aminophenylsulfonyl)amino]propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-acetic acid ,  1-[2-Oxo-2-(3,4-dimethoxyphenyl)ethyl]-2-[(2S)-2-[(4-aminophenylsulfonyl)amino]propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline ,  1-(2-Hydroxy-2-phenylethyl)-2-[(2S)-2-[(4-aminophenylsulfonyl)amino]propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline ,  1-Phenethyl-1,2,3,4-tetrahydroisoquinoline ,  (2S)-1-(1-Phenethyl-1,2,3,4-tetrahydroisoquinoline-2-yl)-2-methoxy-2-phenyl-3,3,3-trifluoro-1-propanone ,  2-[(2S)-2-(1,3-Dioxo-2H-isoindole-2-yl)propionyl]-6,7-dimethoxy-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[(2S)-2-(1,3-Dioxo-2H-isoindole-2-yl)propionyl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  2-[(2S)-2-(4-Nitrophenylsulfonylamino)propionyl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  1-[2-Oxo-2-(3,4-dimethoxyphenyl)ethyl]-2-[(2S)-2-(4-nitrophenylsulfonylamino)propionyl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline ,  1-(2-Oxo-2-phenylethyl)-2-[(2S)-2-(4-nitrophenylsulfonylamino)propionyl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline ,  1-(2-Oxopropyl)-2-[(2S)-2-(4-nitrophenylsulfonylamino)propionyl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline ,  1-Allyl-2-[(2S)-2-(1,3-dioxo-2H-isoindole-2-yl)propionyl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline ,  1-Allyl-2-[(2S)-2-(4-nitrophenylsulfonylamino)propionyl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline ,  6,7-Dimethoxyisoquinoline ,  5,8-Dibromo-6,7-dimethoxyisoquinoline ,  (-)-Homolaudanosine ,  (1R)-2-[(2S)-2-(4-Nitrophenylsulfonylamino)-3-methylbutyryl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  (1R)-2-[(2S)-2-(1,3-Dioxo-2H-isoindole-2-yl)-3-methylbutyryl]-5,8-dibromo-6,7-dimethoxy-1,2-dihydroisoquinoline-1-acetic acid benzyl ester ,  1-(Trimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethene ,  2-(Trimethylsilyloxy)-1-propene

Terms in the title (5)： キラル ,  アラニン誘導体 ,  イソキノリン類 ,  C1 ,  求核試薬