Art

J-GLOBAL ID：200902111896312373   Reference number：00A0552430

Cationic Lipids for Gene Therapy. Part III. Synthesis of High-Mannose Type Neoglycolipids: Active Targeting of Liposomes to Macrophages in Gene Therapy.

遺伝子療法のためのカチオン性脂質 III 高マンノース型ネオ糖脂質の合成 遺伝子療法におけるマクロファージへのリポソームの活性標的化

Author (4)： DUEFFELS A (Univ. Cambridge, Cambridge, GBR) ,  GREEN L G (Univ. Cambridge, Cambridge, GBR) ,  LEY S V (Univ. Cambridge, Cambridge, GBR) ,  MILLER A D (Imperial Coll. Sci. Technol. and Medicine, London, GBR)
Material： Chemistry - European Journal  (Chem Eur J)
Volume： 6  Issue： 8  Page： 1416-1430  Publication year： Apr. 14, 2000 
JST Material Number： W0744A  ISSN： 0947-6539  CODEN： CEUJED  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： Gene Therapy ,...
Semi thesaurus term： Leishmania ,...

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JST classification (3)： Glycosides  (CF10057O) ,  Steroids  (CF10040O) ,  Synthesis of drugs  (GV01030F)

Substance index (32)： 2-O-Benzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-4-O,6-O-benzylidene-1-(phenylseleno)-1-deoxy-α-D-mannopyranose ,  2-O-Benzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-glucopyranosyl)-4-O,6-O-benzylidene-1-(phenylthio)-1-deoxy-α-D-mannopyranose ,  Ethyl 2-O-(2-O-acetyl-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl)-3-O,4-O,6-O-tribenzyl-1-thio-α-D-mannopyranoside ,  Ethyl 2-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-3-O,4-O,6-O-tribenzyl-1-thio-α-D-mannopyranoside ,  2-O,3-O,4-O,6-O-Tetrabenzyl-α-D-mannopyranosyl fluoride ,  9-[2-O,4-O-Dibenzyl-6-O-(tert-butyldiphenylsilyl)-α-D-mannopyranosyloxy]nonanoic acid methyl ester ,  2-O,3-O,4-O,6-O-Tetrabenzyl-α-D-glucopyranosyl fluoride ,  2-O-Benzyl-4-O,6-O-benzylidene-1-(phenylseleno)-1-deoxy-α-D-mannopyranose ,  2-O-Acetyl-3-O,4-O,6-O-tribenzyl-1-(phenylseleno)-1-deoxy-α-D-mannopyranose ,  Phenyl 3-O,4-O,6-O-tribenzyl-1-thio-α-D-mannopyranoside ,  [(2-O,3-O,4-O,6-O-Tetrabenzyl-α-D-mannopyranosyl)seleno]benzene ,  9-[2-O,4-O-Dibenzyl-3-O-[3-O,4-O,6-O-tribenzyl-2-O-(3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanoic acid methyl ester ,  9-[2-O,4-O-Dibenzyl-3-O-[2-O-[2-O-[2-O-benzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-glucopyranosyl)-4-O,6-O-benzylidene-α-D-mannopyranosyl]-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-α-D-mannopyranosyloxy]nonanoic acid methyl ester ,  9-[2-O,4-O-Dibenzyl-3-O-[2-O-[2-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-α-D-mannopyranosyloxy]nonanoic acid methyl ester ,  9-[2-O,4-O-Dibenzyl-3-O-[2-O-[2-O-[2-O-benzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-glucopyranosyl)-4-O,6-O-benzylidene-α-D-mannopyranosyl]-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-6-O-[2-O-benzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-4-O,6-O-benzylidene-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanoic acid methyl ester ,  9-[2-O,4-O-Dibenzyl-3-O-[2-O-[2-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-6-O-[2-O-benzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-4-O,6-O-benzylidene-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanoic acid methyl ester ,  9-[2-O,4-O-Dibenzyl-3-O-[2-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanoic acid methyl ester ,  9-[2-O,4-O-Dibenzyl-3-O-[2-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-6-O-[2-O-benzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-4-O,6-O-benzylidene-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanoic acid methyl ester ,  9-[2-O,4-O-Dibenzyl-3-O-[2-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-3-O,4-O,6-O-tribenzyl-α-D-mannopyranosyl]-6-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-β-D-mannopyranosyloxy]nonanoic acid methyl ester ,  9-[2-O,4-O-Dibenzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-6-O-[2-O-benzyl-3-O-(2-O,3-O,4-O,6-O-tetrabenzyl-α-D-mannopyranosyl)-4-O,6-O-benzylidene-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanoic acid methyl ester ,  Cholesterol chloroformate ,  2-[[4-[(2-Amino-3,4-dioxo-1-cyclobutenyl)amino]butyl][[2-(trimethylsilyl)ethoxy]carbonyl]amino]ethylcarbamic acid cholesta-5-ene-3β-yl ester ,  N-(2-Aminoethyl)-9-[3-O-[2-O-[3-O-(α-D-glucopyranosyl)-α-D-mannopyranosyl]-α-D-mannopyranosyl]-6-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanamide ,  N-(2-Aminoethyl)-9-[2-O,4-O-benzylidene-3-O-[2-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-6-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanamide ,  N-(2-Aminoethyl)-9-[3-O-[2-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-6-O-(α-D-mannopyranosyl)-β-D-mannopyranosyloxy]nonanamide ,  N-(2-Aminoethyl)-9-[2-O,4-O-benzylidene-3-O-(α-D-mannopyranosyl)-6-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanamide ,  N-[2-[[2-[[4-[[2-[(Cholest-5-en-3β-yloxy)carbonylamino]ethyl]amino]butyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]ethyl]-9-[3-O-[2-O-[3-O-(α-D-glucopyranosyl)-α-D-mannopyranosyl]-α-D-mannopyranosyl]-6-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanamide ,  N-[2-[[2-[[4-[[2-[(Cholest-5-en-3β-yloxy)carbonylamino]ethyl]amino]butyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]ethyl]-9-[2-O,4-O-benzylidene-3-O-[2-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-6-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanamide ,  N-[2-[[2-[[4-[[2-[(Cholesta-5-ene-3β-yloxy)carbonylamino]ethyl]amino]butyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]ethyl]-9-[3-O-[2-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-6-O-(α-D-mannopyranosyl)-β-D-mannopyranosyloxy]nonanamide ,  N-[2-[[2-[[4-[[2-[(Cholesta-5-ene-3β-yloxy)carbonylamino]ethyl]amino]butyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]ethyl]-9-[2-O,4-O-benzylidene-3-O-(α-D-mannopyranosyl)-6-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanamide ,  N-(2-Aminoethyl)-9-[3-O-[2-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-α-D-mannopyranosyl]-6-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanamide ,  N-[2-[[2-[[4-[[2-[(Cholest-5-en-3β-yloxy)carbonylamino]ethyl]amino]butyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]ethyl]-9-[3-O-[2-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-α-D-mannopyranosyl]-6-O-[3-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]-β-D-mannopyranosyloxy]nonanamide

Terms in the title (8)： 遺伝子療法 ,  カチオン性脂質 ,  マンノース ,  糖脂質 ,  マクロファージ ,  リポソーム ,  活性 ,  標的化