Art

J-GLOBAL ID：200902113711467948   Reference number：96A0449311

Aryl Phosphoramidate Derivatives of d4T Have Improved Anti-HIV Efficacy in Tissue Culture and May Act by the Generation of a Novel Intracellular Metabolite.

d4Tのアミドりん酸アリール誘導体は組織培養において改善された抗HIV効果を示し,新規細胞内代謝産物の生成により作用する

Author (5)： MCGUIGAN C (Univ. Wales Cardiff, Cardiff, GBR) ,  CAHARD D (Univ. Wales Cardiff, Cardiff, GBR) ,  SHEEKA H M (Univ. Wales Cardiff, Cardiff, GBR) ,  DE CLERCQ E (Univ. Wales Cardiff, Cardiff, GBR) ,  BALZARINI J (Univ. Wales Cardiff, Cardiff, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 39  Issue： 8  Page： 1748-1753  Publication year： Apr. 12, 1996 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： deoxysugar ,...
Semi thesaurus term： thymidine ,...

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JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Pyrimidines  (CF07103W)

Substance index (16)： Zidovudine ,  Stavudine ,  SO-324 ,  N-[3′,5′-Dideoxy-2′,3′-didehydrothymidine-5′-yloxy(phenoxy)phosphinyl]glycine methyl ester ,  1-[5-O-[Phenoxy[[1-(methoxycarbonyl)-2-methylpropyl]amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  1-[5-O-[Phenoxy[[1-(methoxycarbonyl)-3-methylbutyl]amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  5′-O-[Phenoxy[[1-(methoxycarbonyl)-2-phenylethyl]amino]phosphinyl]-3′-deoxy-2′,3′-didehydrothymidine ,  1-[5-O-[Phenoxy[[1-(methoxycarbonyl)-3-(methylthio)propyl]amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  1-[5-O-[(2,4-Dibromophenoxy)[(1-methyl-2-oxo-2-methoxyethyl)amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  2′,3′-Didehydro-3′-deoxythymidine 5′-[[1-(methoxycarbonyl)ethyl]amidophosphoric acid 3-(trifluoromethyl)phenyl] ester ,  1-[5-O-[(Pentafluorophenoxy)[(1-methyl-2-oxo-2-methoxyethyl)amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  1-[5-O-[(3,5-Dichlorophenoxy)[(1-methyl-2-oxo-2-methoxyethyl)amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  1-[5-O-[(4-Ethylphenoxy)[(1-methyl-2-oxo-2-methoxyethyl)amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  1-[5-O-[Methoxy[(1-methyl-2-oxo-2-methoxyethyl)amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  1-[5-O-[Ethoxy[(1-methyl-2-oxo-2-methoxyethyl)amino]phosphinyl]-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl]thymine ,  Alanyl-D4T-MP

Terms in the title (5)： アミドりん酸 ,  誘導体 ,  組織培養 ,  HIV ,  代謝産物