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J-GLOBAL ID：200902113801885536   Reference number：99A0908250

Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II.

DNAトポイソメラーゼIIの阻害活性を有する新規な抗腫ようジヒドロキサントン誘導体の合成

Author (7)： SATO S (Ajinomoto Co., Inc., Kawasaki, JPN) ,  SUGA Y (Ajinomoto Co., Inc., Kawasaki, JPN) ,  YOSHIMURA T (Ajinomoto Co., Inc., Kawasaki, JPN) ,  NAKAGAWA R (Ajinomoto Co., Inc., Kawasaki, JPN) ,  TSUJI T (Ajinomoto Co., Inc., Kawasaki, JPN) ,  UMEMURA K (Soka Univ., Tokyo, JPN) ,  ANDOH T (Soka Univ., Tokyo, JPN)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 9  Issue： 18  Page： 2653-2656  Publication year： Sep. 20, 1999 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...

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JST classification (3)： Condensed derivatives of pyrane  (CF07093I) ,  Synthesis of drugs  (GV01030F) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (19)： Nidulalin A ,  Dihydronidulalin A ,  (4R)-4β,8-Diacetoxy-6-methyl-9-oxo-1,4,4a,9a-tetrahydro-9H-xanthene-4aα-carboxylic acid ,  (4R)-4β,8-Diacetoxy-6-methyl-9-oxo-1,4,4a,9a-tetrahydro-9H-xanthene-4aα-carboxamide ,  (4R)-N,6-Dimethyl-4β,8-diacetoxy-9-oxo-1,4,4a,9a-tetrahydro-9H-xanthene-4aα-carboxamide ,  (4R)-N,N,6-Trimethyl-4β,8-diacetoxy-9-oxo-1,4,4a,9a-tetrahydro-9H-xanthene-4aα-carboxamide ,  (4R)-N-(2-Acetoxyethyl)-4β,8-diacetoxy-6-methyl-9-oxo-1,4,4a,9a-tetrahydro-9H-xanthene-4aα-carboxamide ,  (4R)-4β,8-Diacetoxy-4aα-(morpholinocarbonyl)-6-methyl-9-oxo-1,4,4a,9a-tetrahydro-9H-xanthene ,  (4R)-4β,8-Diacetoxy-6-methyl-9-oxo-4,4a-dihydro-9H-xanthene-4aα-carboxamide ,  (4R)-N,6-Dimethyl-4β,8-diacetoxy-9-oxo-4,4a-dihydro-9H-xanthene-4aα-carboxamide ,  (4R)-N,N,6-Trimethyl-4β,8-diacetoxy-9-oxo-4,4a-dihydro-9H-xanthene-4aα-carboxamide ,  (4R)-N-(2-Acetoxyethyl)-4β,8-diacetoxy-6-methyl-9-oxo-4,4a-dihydro-9H-xanthene-4aα-carboxamide ,  (4R)-4β,8-Diacetoxy-4aα-(morpholinocarbonyl)-6-methyl-9-oxo-4,4a-dihydro-9H-xanthene ,  (4R)-4β,8-Dihydroxy-6-methyl-9-oxo-4,4a-dihydro-9H-xanthene-4aα-carboxamide ,  (4R)-N,6-Dimethyl-4β,8-dihydroxy-9-oxo-4,4a-dihydro-9H-xanthene-4aα-carboxamide ,  (4R)-N,N,6-Trimethyl-4β,8-dihydroxy-9-oxo-4,4a-dihydro-9H-xanthene-4aα-carboxamide ,  (4R)-N-(2-Acetoxyethyl)-4β,8-dihydroxy-6-methyl-9-oxo-4,4a-dihydro-9H-xanthene-4aα-carboxamide ,  (4R)-4β,8-Dihydroxy-4aα-(morpholinocarbonyl)-6-methyl-9-oxo-4,4a-dihydro-9H-xanthene ,  (3S)-4β,8-Dihydroxy-6,12-dimethyl-3α,4aα-(epiminomethano)-2,3,4,4a-tetrahydro-9H-xanthene-9,11-dione

Terms in the title (4)： DNAトポイソメラーゼII ,  阻害活性 ,  腫よう ,  誘導体