Art

J-GLOBAL ID：200902113992705982   Reference number：01A0523803

Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression.

ヒト内皮細胞の細胞接着分子発現抑制薬の発見 1 ICAM-1およびE-セレクチン発現の選択的な抑制

Author (9)： STEWART A O (Abbott Lab., Illinois) ,  BHATIA P A (Abbott Lab., Illinois) ,  MCCARTY C M (Abbott Lab., Illinois) ,  PATEL M V (Abbott Lab., Illinois) ,  KILGANNON P (ICOS Corp., Washington) ,  WISDOM W (ICOS Corp., Washington) ,  MEYER J (ICOS Corp., Washington) ,  GALLATIN W M (ICOS Corp., Washington) ,  OKASINSKI G F (Abbott Lab., Illinois)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 44  Issue： 6  Page： 988-1002  Publication year： Mar. 15, 2001 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...
Semi thesaurus term： A-155918 ,...

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JST classification (2)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Other condensed derivatives of pyridine  (CF07097Y)

Substance index (32)： A-155918 ,  A-205804 ,  3-Isopropoxy-5-methoxybenzo[b]thiophene-2-carboxamide ,  4-(p-Tolylthio)thieno[2,3-c]pyridine-2-methanol ,  4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carbaldehyde ,  1-(4-(p-Tolylthio)thieno[2,3-c]pyridine-2-yl)ethanone ,  2-Benzoyl-4-(p-tolylthio)thieno[2,3-c]pyridine ,  A-236934 ,  4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carbohydrazide ,  N-Methyl-N-methoxy-4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide ,  N-Methoxy-4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide ,  4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carbothioamide ,  N-(2,3-Dihydroxypropyl)-4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide ,  2-[[4-(p-Tolylthio)thieno[2,3-c]pyridine-2-yl]methyleneaminooxy]acetamide ,  1-(4-(p-Tolylthio)thieno[2,3-c]pyridine-2-yl)ethanoneoxime ,  4-Chlorothieno[2,3-c]pyridine-2-carboxamide ,  4-(Phenylthio)thieno[2,3-c]pyridine-2-carboxamide ,  4-(o-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide ,  4-(m-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide ,  4-[(3,4-Dimethylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-[(3,5-Dimethylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-[(2,4-Dimethylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-[[4-(Trifluoromethyl)phenyl]thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-(4-Chlorophenylthio)thieno[2,3-c]pyridine-2-carboxamide ,  4-[(3,4-Dichlorophenyl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-[(4-Bromophenyl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-[(4-Methoxyphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-[(1,1′-Biphenyl-4-yl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-(2-Pyridinylthio)thieno[2,3-c]pyridine-2-carboxamide ,  4-[(2-Methyl-3-furanyl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  4-[(4-Chlorobenzyl)thio]thieno[2,3-c]pyridine-2-carboxamide ,  A-245346

Terms in the title (8)： ヒト ,  内皮細胞 ,  細胞接着分子 ,  発現抑制 ,  発見 ,  ICAM-1 ,  E-セレクチン ,  発現