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J-GLOBAL ID：200902115063131222   Reference number：01A0180943

Dehydroepiandrosterone Suppresses Elevated Hepatic Glucose-6-phosphatase mRNA Level in C57BL/KsJ-db/db Mice. Comparison with Troglitazone.

C57BL/KsJ-db/dbマウスにおける増加した肝臓グルコース-6-ホスファターゼmRNA値のデヒドロエピアンドロテスロンによる抑制 トログリタゾンとの比較

Author (8)： AOKI K (Yokohama City Univ. School of Medicine, Yokohama, JPN) ,  KIKUCHI T (Yokohama City Univ. School of Medicine, Yokohama, JPN) ,  MUKASA K (Yokohama City Univ. School of Medicine, Yokohama, JPN) ,  ITO S (Yokohama City Univ. School of Medicine, Yokohama, JPN) ,  NAKAJIMA A (Yokohama City Univ. School of Medicine, Yokohama, JPN) ,  SATOH S (Yokohama City Univ. School of Medicine, Yokohama, JPN) ,  OKAMURA A (Yokohama City Univ. School of Medicine, Yokohama, JPN) ,  SEKIHARA H (Yokohama City Univ. School of Medicine, Yokohama, JPN)
Material： Endocrine Journal  (Endocr J)
Volume： 47  Issue： 6  Page： 799-804  Publication year： Dec. 2000 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *hypoglycemic drug ,...
Semi thesaurus term： insulin resistance

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JST classification (3)： Adrenal hormones  (EB08040D) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Animal physiology in general  (EJ02010E)

Substance index (2)： Troglitazone ,  Dehydroepiandrosterone

Reference (19)：

• 1). Gunnarsson R (1975) Function of the pancreatic B-Cell during the development of hyperglycemia in mice homozygous for the mutations “diabetes” (db) and “misty” (m). Diabetologia 11: 431-438.
• 2). Coleman DL, Leiter EH, Schwizer RW (1982) Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice. Diabetes 31: 830-833.
• 3). Coleman DL, Schwizer RW, Leiter EH (1984) Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and aged normal mice. Diabetes 33: 26-32.
• 4). Cleary MP (1991) The antiobesity effect of dehydroepiandrosterone in rats. Proc Soc Exp Biol Med 196: 8-16.
• 5). McIntosh MK, Berdanier CD (1991) Antiobesity effects of dehydroepiandrosterone are mediated by futile substrate cycling in hepatocytes of BHE/cbd Rats. J Nutr 121: 2037-2043.

Terms in the title (6)： Db ,  マウス ,  肝臓 ,  グルコース-6-ホスファターゼ ,  mRNA ,  トログリタゾン