Art

J-GLOBAL ID：200902115560825866   Reference number：01A0310712

Synthesis and Biological Activity of the 1α,25-Dihydroxyvitamin D₃ Diastereomer with Unnatural Configuration at the Rings C/D Side-Chain Moiety.

C/D環側鎖部分に非天然型立体配置を持つ1α,25-ジヒドロキシビタミンD₃ジアステレオマの合成及び生物活性

Author (5)： MARCZAK S (Inst. Organic Chemistry, Polish Acad. Sci., Warsaw, POL) ,  PRZEZDZIECKA A (Inst. Organic Chemistry, Polish Acad. Sci., Warsaw, POL) ,  WICHA J (Inst. Organic Chemistry, Polish Acad. Sci., Warsaw, POL) ,  STEINMEYER A (Schering AG, Berlin, DEU) ,  ZUEGEL U (Schering AG, Berlin, DEU)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 11  Issue： 1  Page： 63-66  Publication year： Jan. 08, 2001 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *vitamin D ,...

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JST classification (2)： Vitamin D  (EB07050H) ,  Synthesis of drugs  (GV01030F)

Substance index (21)： Calcitriol ,  MC-1288 ,  (13S,14R,17S,20S)-1α,25-Dihydroxycholecalciferol ,  1-(Phenylthio)-3-buten-2-one ,  2-Methyl-1,3-cyclopentanedione ,  (7aR)-4-(Phenylthio)-7aα-methyl-2,3,5,6,7,7a-hexahydro-1H-indene-1,5-dione ,  (3aβ,4S)-4β-(Phenylsulfonyl)-7aα-methylhydrindane-1-one ,  (1S,3aβ)-4β-(Phenylsulfonyl)-7aα-methylhydrindane-1α-acetic acid ethyl ester ,  1,1-Dimethyl-4-bromobutoxytriethylsilane ,  (αS,1S,3aβ)-α-[4-Methyl-4-(triethylsiloxy)pentyl]-4β-(phenylsulfonyl)-7aα-methylhydrindane-1α-acetic acid ethyl ester ,  (1S,3aβ)-4-(Phenylsulfonyl)-4-[4-methyl-4-(triethylsiloxy)pentyl]-7aα-methylhydrindane-1α-acetic acid ethyl ester ,  (αS,1S,3aβ)-α-[4-Methyl-4-(triethylsiloxy)pentyl]-4β-(phenylsulfonyl)-7aα-methylhydrindane-1α-acetic acid ,  (1S,3aβ)-4-(Phenylsulfonyl)-4-[4-methyl-4-(triethylsiloxy)pentyl]-7aα-methylhydrindane-1α-acetic acid ,  (Z)-2-[2-Methylene-3β,5α-bis(tert-butyldimethylsilyloxy)cyclohexylidene]ethanol ,  2-[(1Z,3S)-2-Methylene-3β,5α-bis(tert-butyldimethylsiloxy)cyclohexylidene]acetaldehyde ,  (6R)-6β,8α-Bis(tert-butyldimethylsiloxy)-5,6,7,8-tetrahydro-1H-2-benzopyran ,  Acetic acid 1-[(1S,3aβ)-1α-[(1S)-1,5-dimethyl-5-(triethylsiloxy)hexyl]-4-(phenylsulfonyl)7aα-methylhydrindane-4-yl]-2-[(1Z,3S)-2-methylene-3β,5α-bis(tert-butyldimethylsiloxy)cyclohexylidene]ethyl ester ,  Acetic acid 1-[(1S,3aβ)-1α-[(1S)-1,5-dimethyl-5-acetoxyhexyl]-4-(phenylsulfonyl)7aα-methylhydrindane-4-yl]-2-[(1Z,3S)-2-methylene-3β,5α-bis(tert-butyldimethylsiloxy)cyclohexylidene]ethyl ester ,  (13S,14R,17S,20S)-1α,3-Bis(tert-butyldimethylsiloxy)-25-(triethylsiloxy)-3-deoxycholecalciferol ,  (13S,14R,17S,20S)-1α,3-Bis(tert-butyldimethylsiloxy)-25-acetoxy-3-deoxycholecalciferol ,  (1S,3aβ)-1α-[(1S)-1,5-Dimethyl-5-(triethylsiloxy)hexyl]-4β-(phenylsulfonyl)7aα-methylhydrindane

Terms in the title (5)： 側鎖 ,  立体配置 ,  ジヒドロキシビタミンD3 ,  ジアステレオマ ,  生物活性