Art

J-GLOBAL ID：200902115849771250   Reference number：99A0708991

Long-Term Open-Trial of Mizoribine with Prednisolone in 24 Patients with Multiple Sclerosis. Safety, Clinical and Magnetic Resonance Imaging Outcome.

多発性硬化症患者24名におけるプレドニゾロン併用ミゾリビン治療の長期オープントライアル 安全性,臨床所見とMRI所見

Author (5)： ZHAO Z (Utano National Hospital, Kyoto) ,  OZAWA K (Utano National Hospital, Kyoto) ,  KONISHI T (Utano National Hospital, Kyoto) ,  SAIDA T (Utano National Hospital, Kyoto) ,  SAIDA K (Nishinara National Hospital, Nara)
Material： Internal Medicine  (Intern Med)
Volume： 38  Issue： 8  Page： 636-642  Publication year： Aug. 1999 
JST Material Number： Z0157B  ISSN： 0918-2918  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *multiple sclerosis ,...

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JST classification (1)： Treatment for immunologic diseases,allergic diseases.  (GD04030Y)

Substance index (2)： Mizoribine ,  Prednisolone

Reference (20)：

• 1) Matthews WB. Matthews WB (ed) McAlpine's Multiple Sclerosis. Churchill Livingstone, Edinburgh London Melborne New york, p251-267, 1991.
• 2) Mizuno K, Tsujino M, Takada M, et al. Studies on bredinin. I. Isolation, characterization and biological properties. J Antibiot (Tokyo) 27: 775-782, 1974.
• 3) Yoshizawa M, Tujino M, Mizuno K, Hayano K. Basic studies on immunosuppression of mizoribine (bredinin). II. Supression of humoral and cellular immune responses.Rinsho Menèki(Clinical Immunology) 14: 561-570, 1982 (in Japanese).
• 4) Hosoda Y, Kato S, Ohhama E. Suppression of relapsing experimental allergic encephalomyelitis by mizoribine: clinical, histological and immunohistochemical studies. Neuropathology 16: 15-20, 1996.
• 5) Mizobuchi M, Sake K, Iwasaki Y, Ohara Y, Terunuma H, Tsunoda I. Suppression of acute active experimental allergic encephalomyelitis with mizoribine is correlated with selective reduction of CD4+CD45RC-cells in the peripheral blood in Lewis rats. Brain Pathology 4: 497, 1994 (Abstract).

Terms in the title (11)： 多発性硬化症 ,  患者 ,  プレドニゾロン ,  併用 ,  ミゾリビン ,  治療 ,  長期 ,  安全性 ,  臨床所見 ,  MRI ,  所見