Art

J-GLOBAL ID：200902115994298139   Reference number：99A0266563

A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuria.

アルカプトン尿症のマウスモデルにおけるホモゲンチジン酸性尿症の新規治療の試み

Author (5)： SUZUKI Y (Kyushu Univ., Beppu, JPN) ,  ODA K (Kyushu Univ., Beppu, JPN) ,  YOSHIKAWA Y (Kyushu Univ., Beppu, JPN) ,  MAEDA T (Kyushu Univ., Beppu, JPN) ,  SUZUKI T (Kyushu Univ., Beppu, JPN)
Material： Journal of Human Genetics  (J Hum Genet)
Volume： 44  Issue： 2  Page： 79-84  Publication year： 1999 
JST Material Number： Z0756A  ISSN： 1434-5161  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *inborn errors of metabolism ,...
Semi thesaurus term： alkaptonuria ,...

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JST classification (3)： Treatment for congenital diseases,deformities.  (GD03030R) ,  Treatment for metabolic diseases,nutritional diseases.  (GD05030F) ,  Enzyme in general  (EB09010D)

Substance index (1)： 2-[2-Nitro-4-(trifluoromethyl)benzyl]-1,3-cyclohexanedione

Reference (20)：

• ELLIS, MK. Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1, 3-dione and 2-(2-chloro-4-metanesulfonylbenzoyl)-cyclohexane-1, 3-dione. Toxicol Appl Pharmacol. 1995, 133, 12-19
• ELLIS, MK. Characterization of the interaction of 2-[2-nitro-4-(trifluoromethyl) benzoyl]-4, 4, 6, 6-tetramethylcyclohexane-1, 3, 5-trione with rat hepatic 4-hydroxyphenylpyruvate dioxygenase. Chem Res Toxicol. 1996, 9, 24-27
• ENDO, F. A murine model for type III tyrosinemia : Lack of immunologically detectable 4-hydroxyphenyl-pyruvic acid dioxygenase enzyme protein in a novel mouse strain with hypertyrosinemia. Am J Hum Genet. 1991, 48, 704-709
• FERNANDEZ-CANON, JM. The molecular basis of alkaptonuria. Nature Genet. 1996, 14, 19-24
• GARROD, AE. The Croonian Lectures on inborn errors of metabolism. Lecture II. Alkaptonuria. Lancet. 1908, II, 73-79

Terms in the title (5)： アルカプトン尿症 ,  マウスモデル ,  酸性尿症 ,  治療 ,  試み