Art

J-GLOBAL ID：200902116127152608   Reference number：99A0912044

A New Century of Pharmacology Is Coming. Probable involvement of the augmented agonist-induced Ca²⁺ sensitization of airway smooth muscle contraction in the pathogenesis of airway hyperresponsiveness.

薬理学の新世紀を拓く アレルギー性気管支ぜん息時の気道過敏性発症機序 過敏性気管支平滑筋におけるCa²⁺感受性の変化

Author (2)： CHIBA YOSHIHIKO (星薬大) ,  MISAWA MIWA (星薬大)
Material： 日本薬理学雑誌  (日本薬理学会西南部会抄録)
Volume： 114  Issue： 3  Page： 185-190  Publication year： Sep. 01, 1999 
JST Material Number： G0740A  ISSN： 0015-5691  CODEN： NYKZA  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *respiratory hypersensitivity ,...
Semi thesaurus term： 気道過敏性 ,...

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JST classification (2)： Basic medicine on respiratory system  (GI01020H) ,  Immunologic diseases,allergic diseases in general.  (GD04010C)

Reference (21)：

• 1) Roberts JA, Raeburn D, Rodger IW and Thomson NC: Comparison of in-vivo responsiveness and in-vitro smooth muscle sensitivity to methacholine. Thorax 39, 837-843 (1984)
• 2) De Jongste JC, Mons H, Bonta IL and Kerrebijn KF: In vitro responses of airways from an asthmatic patients. Eur J Respir Dis 71, 23-29 (1987)
• 3) Sato K, Ozaki H and Karaki H: Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator Fura 2. J Pharma col Exp Ther 246, 294-300 (1988)
• 4) Ozaki H, Kwon S-C, Tajimi M and Karaki H: Changes in cytosolic Ca²⁺ and contraction induced by various stimulants and relaxants in canine tracheal smooth muscle. Pflugers Arch 416, 351-359 (1990)
• 5) Somlyo AP and Somlyo AV: Signal transduction and regulation in smooth muscle. Nature 372, 231-236 (1994)

Terms in the title (7)： 薬理学 ,  気管支ぜん息 ,  気道過敏性 ,  発症機序 ,  過敏性 ,  気管支平滑筋 ,  Ca2+感受性