Art

J-GLOBAL ID：200902117450589264   Reference number：02A0656352

Effect of the Intestinal Flora on Amyloid Deposition in a Transgenic Mouse Model of Familial Amyloidotic Polyneuropathy.

家族性アミロイド多発神経症モデルトランスジェニックマウスのアミロイド沈着への腸内フローラの影響

Author (9)： NOGUCHI H (Kumamoto Univ., Kumamoto, JPN) ,  WAKASUGI S (Kumamoto Univ. School of Medicine, Kumamoto, JPN) ,  NOGUCHI K (Center for Animal Resources and Dev., Kumamoto, JPN) ,  NAKAMURA N (Center for Animal Resources and Dev., Kumamoto, JPN) ,  NAKAMURA O (Kumamoto Univ. School of Medicine, Kumamoto, JPN) ,  MIYAKAWA K (Kumamoto Univ. School of Medicine, Kumamoto, JPN) ,  SUZUKI M (Center for Animal Resources and Dev., Kumamoto, JPN) ,  NAKAGATA N (Center for Animal Resources and Dev., Kumamoto, JPN) ,  YAMAMURA K (Kumamoto Univ., Kumamoto, JPN)
Material： Experimental Animals  (実験動物ニュース)
Volume： 51  Issue： 4  Page： 309-316  Publication year： Jul. 2002 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： transgenic mouse ,...
Semi thesaurus term： *amyloidosis ,...

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JST classification (2)： Microorganism ecology  (EG03040J) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Reference (25)：

• 1. Yamamura, K., Wakasugi, S., Maeda, S., Inomoto, T., Iwanaga, T., Uehira, M., Araki, K., Miyazaki, J., and Shimada, K. 1987. Tissue-specific and developmental expression of human transthyretin gene in transgenic mice. Dev. Genet. 8: 195-205.
• 2. Wakasugi, S., Inomoto, T., Yi, S., Naito, M., Uehira, M., Iwanaga, T., Maeda, S., Araki, K., Miyazaki, J., Takahashi, K., Shimada, K., and Yamamura, K. 1987. A transgenic mouse model of familial amyloidotic polyneuropathy. Proc. Japan. Acad. 63: 344-347.
• 3. Nagata, Y., Tashiro, F., Yi, S., Murakami, T., Maeda, S., Takahashi, K., Shimada, K., Okamura, H., and Yamamura, K. 1995. A 6-Kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse. J. Biochem. 117: 169-175.
• 4. Connors, L.H., Richardson, A.M., Thébrege, R., and Costello, C.E. 2000. Sequence communication; tabulation of transthyretin (TTR) variants as of 1/1/2000. Amyloid: Int. J. Exp. Clin. Invest. 7: 54-69.
• 5. Holmgren, G., Bergstöm, S., Drugge, U., Lundgren, E., Nording-Sikstöm, C., Sandgren, O., and Steen, L. 1992. Homozygosity for the transthyretin-Met30-gene in seven individuals with familial amyloidosis with polyneuropathy detected by restriction enzyme analysis of amplified genomic DNA sequences. Clin. Genet. 41: 39-41.

Terms in the title (7)： 家族 ,  アミロイド ,  神経症 ,  モデル ,  トランスジェニックマウス ,  アミロイド沈着 ,  腸内フローラ