Art

J-GLOBAL ID：200902117874260807   Reference number：94A0660325

The Discovery of Capsazepine, the First Competitive Antagonist of the Sensory Neuron Excitants Capsaicin and Resiniferatoxin.

知覚ニューロン興奮剤カプサイシンやレシニフェラトキシンの競争的きっ抗薬としてのカプサゼピンの開発

Author (9)： WALPOLE C S J (Sandoz Inst. Medical Research, London, GBR) ,  BEVAN S (Sandoz Inst. Medical Research, London, GBR) ,  VOBERMANN G (Sandoz Inst. Medical Research, London, GBR) ,  BOELSTERLI J J (Sandoz Inst. Medical Research, London, GBR) ,  BRECKENRIDGE R (Sandoz Inst. Medical Research, London, GBR) ,  DAVIES J W (Sandoz Inst. Medical Research, London, GBR) ,  HUGHES G A (Sandoz Inst. Medical Research, London, GBR) ,  JAMES I (Sandoz Inst. Medical Research, London, GBR) ,  WRIGGLESWORTH R (Sandoz Inst. Medical Research, London, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 37  Issue： 13  Page： 1942-1954  Publication year： Jun. 24, 1994 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： sensory nerve ,...
Semi thesaurus term： レシニフェラトキシン ,...

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JST classification (2)： Basic research of psychotropic drugs  (GW03100Y) ,  Aromatic monocyclic ureas,carbamic acids,guanidines  (CF05220O)

Substance index (11)： Capsazepine ,  1-(4-Hydroxy-3-methoxybenzyl)-3-octylthiourea ,  1-(4-Hydroxy-3-methoxybenzyl)-3-(4-chlorophenethyl)thiourea ,  1,2,3,4-Tetrahydro-N-octyl-6,7-dihydroxyisoquinoline-2-carbothioamide ,  1,2,3,4-Tetrahydro-N-(4-chlorophenethyl)-6,7-dihydroxyisoquinoline-2-carbothioamide ,  1,2,3,4-Tetrahydro-N-(4-chlorophenethyl)-6-hydroxy-7-methoxyisoquinoline-2-carbothioamide ,  1,2,3,4-Tetrahydro-N-(4-chlorophenethyl)-7-hydroxy-6-methoxyisoquinoline-2-carbothioamide ,  1,2,3,4-Tetrahydro-N-octyl-5,6-dihydroxyisoquinoline-2-carbothioamide ,  1,3-Dihydro-5,6-dihydroxy-N-(4-chlorophenethyl)-2H-isoindole-2-carbothioamide ,  1,3-Dihydro-5-hydroxy-6-methoxy-N-(4-chlorophenethyl)-2H-isoindole-2-carbothioamide ,  2,3,4,5-Tetrahydro-7,8-dimethoxy-N-(4-chlorophenethyl)-1H-2-benzazepine-2-carbothioamide

Terms in the title (9)： 知覚 ,  ニューロン ,  興奮 ,  カプサイシン ,  レシニフェラトキシン ,  競争 ,  きっ抗薬 ,  カプサゼピン ,  開発