Art

J-GLOBAL ID：200902118920462530   Reference number：94A0205372

Totally syntheticanalogues of siastatin B. III. Trifluoroacetamide analogues having inhibitory activity for tumor metastasis.

シアスタチンBの全合成類縁体 III 腫よう転移阻害活性を有するトリフルオロアセトアミド類縁体

Author (7)： NISHIMURA Y (Inst. Microbial Chemistry, Tokyo, JPN) ,  KUDO T (Inst. Microbial Chemistry, Tokyo, JPN) ,  KONDO S (Inst. Microbial Chemistry, Tokyo, JPN) ,  TAKEUCHI T (Inst. Microbial Chemistry, Tokyo, JPN) ,  TSURUOKA T (Meiji Seika Kaisha, Ltd., Tokyo, JPN) ,  FUKUYASU H (Meiji Seika Kaisha, Ltd., Tokyo, JPN) ,  SHIBAHARA S (Meiji Seika Kaisha, Ltd., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 47  Issue： 1  Page： 101-107  Publication year： Jan. 1994 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： enzyme inhibitor ,...
Semi thesaurus term： シアスタチンB ,...

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JST classification (2)： Synthesis of antibiotics  (GX04000Z) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (5)： SF-4 ,  (4S,5R,6S)-3-[(Z)-Benzyloxymethylene]-1-(tert-butoxycarbonyl)-6-(trifluoroacetyl)amino-4,5-(isopropylidenedioxy)piperidine ,  (4S,5R,6S)-3-[(E)-Benzyloxymethylene]-1-(tert-butoxycarbonyl)-6-(trifluoroacetyl)amino-4,5-(isopropylidenedioxy)piperidine ,  (3S,4S,5R,6S)-3-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)-6-(trifluoroacetyl)amino-4,5-(isopropylidenedioxy)piperidine ,  (3S,4S,5R,6S)-1-(tert-Butoxycarbonyl)-6-(trifluoroacetyl)amino-4,5-(isopropylidenedioxy)piperidine-3-carboxylic acid

Reference (30)：

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• 3) TWUNSTRA, A.; A. P. VANZANTEN, W. J. NOOYEN & B. W. ONGERBOER DE VISSER: Sensitivity and specificity of single and combined tumor markers in the diagnosis of leptomeningeal metastasis from breast cancer. J. Neurol. Neurosurg. Psychiatry 49: 1246-1250, 1986
• 4) NAKAO, H.; K. TAKAMORI & H. OGAWA: Interaction of tumor and surrounding tissue of mice inoculated B16 melanoma variants in terms of enzyme activity. Int. J. Biochem. 21: 739-743, 1989
• 5) TWUNSTRA, A.; B. W. ONGERBOER DE VISSER, A. P. VAN ZANTEN, A. A. M. HART & W. J. NOOYEN: Serial lumber and ventricular cerebrospinal fluid biochemical marker measurements in patients with leptomeningeal metastases from solid and hematological tumors. J. Neurooncol. 7: 57-64, 1989
• 6) KEREN, Z.; F. LELAND, M. NAKAJIMA & S. J. LEGRUE: Inhibition of experimental metastasis and extracellular matrix degradation by butanol extracts from B16-F1 murine melanoma. Cancer Res. 49: 295-300, 1989

Terms in the title (6)： シアスタチンB ,  全合成 ,  類縁体 ,  腫よう転移 ,  阻害活性 ,  トリフルオロアセトアミド