Art

J-GLOBAL ID：200902118962935918   Reference number：96A0262376

Synthesis and Anti-Herpes Virus Activity of 2′-Deoxy-4′-thiopyrimidine Nucleosides.

2′-デオキシ-4′-チオピリミジンヌクレオシドの合成と抗ヘルペスウイルス作用

Author (9)： RAHIM S G (Wellcome Res. Lab., Kent, GBR) ,  TRIVEDI N (Wellcome Res. Lab., Kent, GBR) ,  BOGUNOVIC-BATCHELOR M V (Wellcome Res. Lab., Kent, GBR) ,  HARDY G W (Wellcome Res. Lab., Kent, GBR) ,  MILLS G (Wellcome Res. Lab., Kent, GBR) ,  SELWAY J W T (Wellcome Res. Lab., Kent, GBR) ,  SNOWDEN W (Wellcome Res. Lab., Kent, GBR) ,  LITTLER E (Wellcome Res. Lab., Kent, GBR) ,  WALKER R T (Univ. Birmingham, Edgbaston, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 39  Issue： 3  Page： 789-795  Publication year： Feb. 02, 1996 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： pyrimidine nucleoside ,...
Semi thesaurus term： 単純ほう疹ウイルス

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JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Nucleosides,nucleotides  (CF10060K)

Substance index (29)： 1-(2-Deoxy-4-thio-α-D-erythro-pentofuranosyl)-5-ethyluracil ,  α-Methyl-4′-O-thiathymidine ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-isopropyluracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-cyclopropyluracil ,  1-[4α-Hydroxy-5β-(hydroxymethyl)thiolan-2-yl]-5-(1-methylpropyl)uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-tert-butyluracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-(adamantan-1-yl)uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-[(E)-1-propenyl]uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-ethynyluracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-(1-propynyl)uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-(2-methoxyethyl)uracil ,  1-[4α-Hydroxy-5β-(hydroxymethyl)thiolan-2-yl]-5-(1-hydroxyethyl)uracil ,  1-(2-Deoxy-4-thio-α-D-erythro-pentofuranosyl)-5-(trifluoromethyl)uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-(trifluoromethyl)uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-(2-fluoroethyl)uracil ,  1-[4α-Hydroxy-5β-(hydroxymethyl)thiolan-2-yl]-5-(2-chloroethyl)uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-(2,2,2-trifluoroethyl)uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-(2,2-difluoroethenyl)uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-[(E)-2-chloroethenyl]uracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-(1-fluoro-2,2-dichloroethenyl)uracil ,  1-[4α-Hydroxy-5β-(hydroxymethyl)thiolan-2-yl]-5-(methylthiomethyl)uracil ,  1-[4α-Hydroxy-5β-(hydroxymethyl)thiolan-2-yl]-5-methoxyuracil ,  1-[4α-Hydroxy-5β-(hydroxymethyl)thiolan-2-yl]-5-fluorouracil ,  ⁷⁷Br-BTdU ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-iodouracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-cyanouracil ,  1-(2-Deoxy-4-thio-α-D-erythro-pentofuranosyl)-5-nitrouracil ,  1-(2-Deoxy-4-thio-β-D-erythro-pentofuranosyl)-5-nitrouracil ,  1-(2-Deoxy-4-thio-D-erythro-pentofuranosyl)-1,5,6,7-tetrahydro-2H-cyclopentapyrimidine-2,4(3H)-dione