Art

J-GLOBAL ID：200902120544960587   Reference number：01A0048460

Mechanism-based Pharmacokinetics and Pharacodynamics. Future Perspectives.

メカニズム・ベースPK/PD 将来展望

Author (1)： HAKUSUI HIDEO (第一製薬 創剤代謝研)
Material： 薬物動態  (Xenobiotic Metabolism and Disposition)
Volume： 15  Issue： 5  Page： 478-483  Publication year： Oct. 31, 2000 
JST Material Number： X0758A  ISSN： 0916-1139  CODEN： YADOEL  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *pharmacokinetics ,...

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JST classification (2)： Basic biopharmacy  (GY01021U) ,  Research and development  (GU01040N)

Reference (14)：

• 1) Breimer D. D. and Danhof M.: Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The ‘Wooden Shoe’ Paradigm. Clin Pharmacokinet. 32: 259-267 (1997).
• 2) Peck C. C., Barr W. H., Benet L. Z., Collins J., Desjardins R. E., Furst D. E., Hater J. G., Levy G., Ludden T., Rodman J. H., Sanathanan L., Schentag J. J., Shah V. P., Sheiner L. B., Skelly G. P., Stanski D. R., Temple R. J., Viswanathan C. T., Weissinger J. and Yacobi A.: Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Clin Pharmacol Ther 51: 465-473 (1992).
• 3) Dettli L.: Elimination Kinetics and Drug Dosage Adjustment of Drugs in Patients with Kidney Disease. Progress in Pharmacology Vol. 1, NO 4, Gustav Fischer, Stuttgart: 1-34 (1972).
• 4) Rowland M., Benet L.Z. and Graham G. G.: Clearance concepts in pharmacokinetics. J Pharmacokinet Biopharm 1: 123-135 (1973).
• 5) Wilkinson G. R. and Shand D. G.: A physiologic approach to hepatic drug clearance. Clin Pharmacol Ther. 18: 377-390 (1975).

Terms in the title (3)： メカニズム ,  PD ,  将来展望