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J-GLOBAL ID：200902120557453994   Reference number：01A0185985

Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3′,5′-bis(trifluoromethyl)-phenyl)carboxamide].

NF-κB及びAP-1遺伝子発現の阻害剤 2-クロロ-4-トリフルオロメチルピリミジン-5-[N-(3’,5’-ビス(トリフルオロメチル)フェニル)カルボキシアミド]のピリミジン部分のSAR研究

Author (9)： PALANKI M S S (Signal Pharmaceuticals, Inc., California) ,  ERDMAN P E (Signal Pharmaceuticals, Inc., California) ,  GAYO-FUNG L M (Signal Pharmaceuticals, Inc., California) ,  SHEVLIN G I (Signal Pharmaceuticals, Inc., California) ,  SULLIVAN R W (Signal Pharmaceuticals, Inc., California) ,  GOLDMAN M E (Signal Pharmaceuticals, Inc., California) ,  RANSONE L J (Signal Pharmaceuticals, Inc., California) ,  BENNETT B L (Signal Pharmaceuticals, Inc., California) ,  MANNING A M (Signal Pharmaceuticals, Inc., California)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 43  Issue： 21  Page： 3995-4004  Publication year： Oct. 19, 2000 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...
Semi thesaurus term： T lymphocyte

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JST classification (2)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D) ,  Pyrimidines  (CF07103W)

Substance index (22)： SP-100030 ,  N-(3,5-Dichlorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloropyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-methylpyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-ethylpyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-propylpyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(pentafluoroethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2,4-dichloropyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-phenylpyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(2-thienyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-fluoro-4-(trifluoromethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-methyl-4-(trifluoromethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2,4-bis(trifluoromethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-cyano-4-(trifluoromethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-(trifluoromethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-phenylpyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-2-(trifluoromethyl)pyrimidine-5-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-2-(trifluoromethyl)-4-chlorobenzamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-4-(trifluoromethyl)-6-chloropyridazine-3-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-6-chloropyridazine-3-carboxamide ,  N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloropyrazine-2-carboxamide

Terms in the title (10)： NF-κB ,  AP-1 ,  遺伝子発現 ,  阻害剤 ,  ビス ,  フェニル ,  カルボキシアミド ,  ピリミジン ,  SAR ,  研究