Art

J-GLOBAL ID：200902121244815786   Reference number：96A0179603

Comparison of Tacrolimus (FK506) Levels Determined by Three Different Methods in the Rat Blood.

ラットにおける血中タクロリムス(FK506)濃度の3方法による測定の比較

Author (8)： IWASAKI K (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  MATSUDA H (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  SHIRAGA T (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  KAWAMURA A (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  MIYAZAKI Y (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  TERAMURA Y (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  TOZUKA Z (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN) ,  HATA T (Fujisawa Pharmaceutical Co., Ltd., Osaka, JPN)
Material： 薬物動態  (Xenobiotic Metabolism and Disposition)
Volume： 10  Issue： 6  Page： 837-847  Publication year： Dec. 1995 
JST Material Number： X0758A  ISSN： 0916-1139  CODEN： YADOEL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： immunosuppressant ,...
Semi thesaurus term： tacrolimus ,...

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JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (1)： Tacrolimus

Reference (6)：

• 1) K. Tamura, M. Kobayashi, K. Hashimoto, K. Kojima, K. Nagase, K. Iwasaki, T. Kaizu, H. Tanaka, and M. Niwa: A highly sensitive method to assay FK-506 levels in plasma. Transplant. Proc., 19 (suppl. 6); 23-29 (1987).
• 2) Japanese FK 506 Study Group; Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Transplant. Proc., 23: 3085-3088 (1991).
• 3) K. Iwasaki, T. Shiraga, K. Nagase, K. Hirano, K. Nozaki, and K. Noda: Pharmacokinetic study of FK 506 in the rat. Transplant. Proc., 23: 2757-2759 (1991).
• 4) K. Iwasaki, T. Shiraga, K. Nagase, Z. Tozuka, K. Noda, S. Sakuma, T. Fujitsu, K. Shimatani, A. Sato, and M. Fujioka: Isolation, identification, and biological activities of oixdative metabolites of FK506, a potent immunosuppressive macrolide lactone. Drug Metab. Dispos., 21: 971-977 (1993).
• 5) K. Iwasaki, T. Shiraga, H. Matsuda, K. Nagase, Y. Tokuma, T. Hata, Y. Fujii, S. Sakuma, T. Fujitsu, A. Fujikawa, K. Shimatani, A. Sato, and M. Fujioka: Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506. Drug Metab. Dispos., 23: 28-34 (1995).

Terms in the title (4)： ラット ,  血 ,  タクロリムス ,  FK506