Art

J-GLOBAL ID：200902122010025281   Reference number：02A0117710

New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models.

多剤耐性細胞系への活性とネズミ腫ようモデルへのin vivo効力を持つ新規抗有糸分裂薬

Author (9)： SZCZEPANKIEWICZ B G (Abbott Lab., Illinois) ,  LIU G (Abbott Lab., Illinois) ,  JAE H-S (Abbott Lab., Illinois) ,  TASKER A S (Abbott Lab., Illinois) ,  GUNAWARDANA I W (Abbott Lab., Illinois) ,  VON GELDERN T W (Abbott Lab., Illinois) ,  GWALTNEY S L II (Abbott Lab., Illinois) ,  WU-WONG J R (Abbott Lab., Illinois) ,  ROSENBERG S H (Abbott Lab., Illinois)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 44  Issue： 25  Page： 4416-4430  Publication year： Dec. 06, 2001 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...
Semi thesaurus term： bridged compound ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=02A0117710&from=J-GLOBAL&jstjournalNo=D0102A") }}

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Oxazoles,isoxazoles  (CF07080Y)

Substance index (26)： Paclitaxel ,  A-105972 ,  A-204197 ,  2-[3-(Dimethylamino)phenyl]-4-acetyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-acetyl-5-(2,3,4-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-acetyl-5-(3,4,5-trimethylphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-acetyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-(3-Methyl-4-aminophenyl)-4-acetyl-5-[4-(methoxycarbonyl)-3,5-dimethoxyphenyl]-4,5-dihydro-1,3,4-oxadiazole ,  2-(3-Methyl-4-aminophenyl)-4-acetyl-5-(7-methoxy-1,3-benzodioxole-5-yl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-formyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-(acetoxyacetyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-(azidoacetyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-(hydroxyacetyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-(aminoacetyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-[(formylamino)acetyl]-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-[(acetylamino)acetyl]-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazole ,  2-[4-(Dimethylamino)phenyl]-4-[(formylamino)acetyl]-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3,4-thiadiazole ,  2-[4-(Dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-2-oxazoline ,  2-[4-(Dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-1,3-dioxolane ,  2-(3-Amino-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-2-oxazoline ,  2-(3-Amino-4-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-2-oxazoline ,  2-(2-Oxo-2,3-dihydrobenzoxazole-6-yl)-5-(3,4,5-trimethoxyphenyl)-2-oxazoline ,  2-(1-Methyl-1,2,3,4-tetrahydroquinoline-6-yl)-5-(3,4,5-trimethoxyphenyl)-2-oxazoline ,  2-(1-Methyl-2,3-dihydro-1H-indole-5-yl)-5-(3,4,5-trimethoxyphenyl)-2-oxazoline ,  2-(1-Methyl-1H-indole-5-yl)-5-(3,4,5-trimethoxyphenyl)-2-oxazoline ,  2-(1H-Indole-5-yl)-5-(3,4,5-trimethoxyphenyl)-2-oxazoline

Terms in the title (7)： 多剤耐性 ,  細胞系 ,  活性 ,  ネズミ ,  腫よう ,  モデル ,  抗有糸分裂薬