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J-GLOBAL ID:200902122204085021   Reference number:02A0805406

Troglitazone Ameliorates Abnormal Activity of Protein Tyrosine Phosphatase in Adipose Tissues of Otsuka Long-Evans Tokushima Fatty Rats.

Otsuka Long-Evans Tokushima肥満ラットの脂肪組織における蛋白質チロシンホスファターゼ異常活性のトログリタゾンによる低下
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Material:
Volume: 197  Issue:Page: 169-181  Publication year: Jul. 2002 
JST Material Number: G0649A  ISSN: 0040-8727  CODEN: TJEMAO  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: ENGLISH (EN)
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Metabolic diseases,nutritional diseases in general.  ,  Basic research of drugs acting on carbohydrate metabolism 
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Reference (43):
  • Abel, E.D., Peroni, O., Kim, J.K., Kim, Y.-B., Boss, O., Hadro, E., Minnemann, T., Shulman, G.I. & Kahn, B.B. (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature, 409, 729-733.
  • Ahmad, F. & Goldstein, B.J. (1995) Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity and diabetes mellitus. Metabolism, 44, 1175-1184.
  • Ahmad, F., Considine, R.V. & Goldstein, B.J. (1995) Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects. J. Clin. Invest., 95, 2806-2812.
  • Ahmad, F., Azevedo, J.L., Cortright, R., Dohm, G.L. & Goldstein, B.J. (1997a) Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. J. Clin. Invest., 100, 449-458.
  • Ahmad, F., Considine, R.V., Bauer, T.L., Ohannesian, J.P., Marco, C.C. & Goldstein, B.J. (1997b) Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue. Metabolism, 46, 1140-1145.
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