Art

J-GLOBAL ID：200902122688187613   Reference number：96A0323923

Synthesis and Antimetastatic Activity of 6-Trichloroacetamido and 6-Guanidino Analogues of Siastatin B.

シアスタチンBの6-トリクロロアセトアミド類縁体と6-グアニジノ類縁体の合成と抗転移活性

Author (9)： SATOH T (Inst. Microbial Chemistry. Tokyo, JPN) ,  NISHIMURA Y (Inst. Microbial Chemistry. Tokyo, JPN) ,  KONDO S (Inst. Microbial Chemistry. Tokyo, JPN) ,  TAKEUCHI T (Inst. Microbial Chemistry. Tokyo, JPN) ,  AZETAKA M (Meiji Seika Kaisha, Ltd., Yokohama, JPN) ,  FUKUYASU H (Meiji Seika Kaisha, Ltd., Yokohama, JPN) ,  IIZUKA Y (Meiji Seika Kaisha, Ltd., Yokohama, JPN) ,  OHUCHI S (Meiji Seika Kaisha, Ltd., Yokohama, JPN) ,  SHIBAHARA S (Meiji Seika Kaisha, Ltd., Yokohama, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 49  Issue： 3  Page： 321-325  Publication year： Mar. 1996 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antibiotics ,...
Semi thesaurus term： シアスタチンB ,...

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JST classification (1)： Synthesis of antibiotics  (GX04000Z)

Substance index (5)： Siastatin B ,  SF-4 ,  [2R,(+)]-2α-(Trifluoroacetylamino)-3β,4β,5-trihydroxypiperidine-5β-carboxylic acid ,  (3S,4S,5R,6R)-6-[(Trichloroacetyl)amino]-4,5-dihydroxy-3-piperidinecarboxylic acid ,  (3S,4S,5R,6R)-6-Guanidino-4,5-dihydroxy-3-piperidinecarboxylic acid

Reference (26)：

• 1) NAKAO, H.; K. TAKAMORI & H. OGAWA: Interaction of tumor and surrounding tissue of mice inoculated B16 melanoma variants in terms of enzyme activity. Int. J. Biochem. 21: 739-743, 1989
• 2) TWIJNSTRA, A.; B. W. ONGEBOER DE VISSER, A. P. VAN ZANTEN, A. A. M. HART & W. J. NOOYEN: Serial lumbar and ventricular cerebrospinal fluid biochemical marker measurements in patients with leptomeningeal metastases from solid and hematological tumors. J. Neuro-oncol. 7: 57-63, 1989
• 3) KEREN, Z.; F. LELAND, M. NAKAJIMA & S. J. LEGRUE: Inhibition of experimental metastasis and extracellular matrix degradation by butanol extracts from B16-F1 murine melanoma. Cancer Res. 49: 295-300, 1989
• 4) NAKAJIMA, M.; K. MORIKAWA, A. FABRA, C. D. BUCANA & I. J. FIDLER: Influence of organ environment on extracellular matrix degradative activity and metastasis of human color carcinoma cells. J. Natl. Cancer Inst. 82: 1890-1898, 1990
• 5) JIN, L.; M. NAKAJIMA & G. L. NICOLSON: Immunochemical localization of heparanase in mouse and human melanomas. Int. J. Cancer 45: 1088-1095, 1990

Terms in the title (5)： シアスタチンB ,  トリクロロアセトアミド ,  類縁体 ,  抗転移 ,  活性