Art

J-GLOBAL ID：200902124330352380   Reference number：00A0333468

Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action.

持続作用活性のエンドセリン変換酵素1に対する強力且つ選択的非ペプチド系阻害剤

Author (9)： DE LOMBAERT S (Novartis Inst. Biomedical Res., New Jersey) ,  BLANCHARD L (Novartis Inst. Biomedical Res., New Jersey) ,  STAMFORD L B (Novartis Inst. Biomedical Res., New Jersey) ,  TAN J (Novartis Inst. Biomedical Res., New Jersey) ,  WALLACE E M (Novartis Inst. Biomedical Res., New Jersey) ,  SATOH Y (Novartis Inst. Biomedical Res., New Jersey) ,  FITT J (Novartis Inst. Biomedical Res., New Jersey) ,  HOYER D (Novartis Inst. Biomedical Res., New Jersey) ,  JENG A Y (Novartis Inst. Biomedical Res., New Jersey)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 43  Issue： 3  Page： 488-504  Publication year： Feb. 10, 2000 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *endothelin antagonist ,...
Semi thesaurus term： エンドセリン変換酵素阻害剤 ,...

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JST classification (2)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Organop phosphorus compounds  (CF08040N)

Substance index (25)： CGS-26303 ,  [1-(1-Sodio-1H-tetrazole-5-yl)-2-(9H-fluorene-2-yl)ethylamino]methylphosphonic acid disodium salt ,  [1-(1-Sodio-1H-tetrazole-5-yl)-2-(9-methyl-9H-carbazole-2-yl)ethylamino]methylphosphonic acid disodium salt ,  [1-(1-Sodio-1H-tetrazole-5-yl)-2-(9-oxo-9H-fluorene-2-yl)ethylamino]methylphosphonic acid disodium salt ,  CGS-34043 ,  CGS-35066 ,  (S)-N-[2-(4-Biphenylyl)ethyl]-α-(phosphonomethylamino)dibenzofuran-3-propionamide ,  (S)-N-Phenethyl-α-(phosphonomethylamino)dibenzofuran-3-propionamide ,  3-(Dibenzofuran-3-yl)-N-(phosphonomethyl)-Ala-Phe-OH ,  3-(Dibenzofuran-3-yl)-N-(phosphonomethyl)-Ala-Leu-OH ,  3-(Dibenzofuran-3-yl)-N-(phosphonomethyl)-Ala-βAla-OH ,  3-(Dibenzofuran-3-yl)-N-(phosphonomethyl)-Ala-Gly-OH ,  (S)-N-[(S)-2-(Dibenzofuran-3-yl)-1-carboxyethyl]-α-(phosphonomethylamino)dibenzofuran-3-propionamide ,  (S)-α-[1-Phosphono-3-(1-naphthyl)propylamino]dibenzofuran-3-propionic acid ,  (S)-α-[1-Phosphono-3-(2,3-dimethoxyphenyl)propylamino]dibenzofuran-3-propionic acid ,  (S)-α-[1-Phosphono-3-(3,4-dimethoxyphenyl)propylamino]dibenzofuran-3-propionic acid ,  (S)-α-[1-Phosphono-3-(3,4,5-trimethoxyphenyl)propylamino]dibenzofuran-3-propionic acid ,  (S)-α-[1-Phosphono-3-(3,4,6-trimethoxyphenyl)propylamino]dibenzofuran-3-propionic acid ,  (S)-α-[1-Phosphono-3-(2,3,4-trimethoxyphenyl)propylamino]dibenzofuran-3-propionic acid ,  (S)-α-[1-Phosphono-3-(8-quinolyl)propylamino]dibenzofuran-3-propionic acid ,  (S)-α-[(1-Phosphono-5-aminopentyl)amino]dibenzofuran-3-propionic acid ,  (S)-α-[(1-Phosphono-4-aminobutyl)amino]dibenzofuran-3-propionic acid ,  (S)-α-[(1-Phosphono-5-methylhexyl)amino]dibenzofuran-3-propionic acid ,  (S)-α-[(1-Phosphonoethyl)amino]dibenzofuran-3-propionic acid ,  3-(1-Naphthyl)-1-[[(S)-1-(1H-tetrazol-5-yl)-2-(dibenzofuran-3-yl)ethyl]amino]propylphosphonic acid

Terms in the title (5)： 持続作用 ,  活性 ,  エンドセリン変換酵素 ,  ペプチド ,  阻害剤