Art

J-GLOBAL ID：200902125962671917   Reference number：93A0773342

Angelmicins, new inhibitors of oncogenic src signal transduction.

癌遺伝子srcシグナル伝達の新阻害剤アンゲルミシン類

Author (9)： UEHARA Y (National Inst. Health, Tokyo, JPN) ,  LI P-M (National Inst. Health, Tokyo, JPN) ,  FUKAZAWA H (National Inst. Health, Tokyo, JPN) ,  MIZUNO S (National Inst. Health, Tokyo, JPN) ,  NIHEI Y (Bristol-Myers Squibb Research Inst., Tokyo, JPN) ,  NISHINO M (Bristol-Myers Squibb Research Inst., Tokyo, JPN) ,  HANADA M (Bristol-Myers Squibb Research Inst., Tokyo, JPN) ,  YAMAMOTO C (Bristol-Myers Squibb Research Inst., Tokyo, JPN) ,  OKI T (Bristol-Myers Squibb Research Inst., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 46  Issue： 8  Page： 1306-1308  Publication year： Aug. 1993 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： oncogene ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (1)： Basic research of antitumor(=antineoplastic)antibiotics  (GX05040Y)

Reference (5)：

• 1) BROWDER, T. M.; C. E. DUNBAR & A. W. NIENHUIS: Private and public autocrine loops in neoplastic cells. Cancer Cells 1: 9-17, 1989
• 2) LI, P-M.; H. FUKAZAWA, C. YAMAMOTO, S. MIZUNO, K. TANAKA, M. HORI, S. YAGINUMA, T. SAITO & Y. UEHARA: Method of identifying inhibitors of oncogenic transformation: selective inhibition of cell growth in serum-free medium. Oncogene 8: 1731 - 1735, 1993
• 3) UEHARA, Y.; Y. MURAKAMI, S. MIZUNO & S. KAWAI: Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A. Virology 164: 294 - 298, 1988
• 4) FUKAZAWA, H; P-M. Li, S. MIZUNO & Y. UEHARA: Method for simultaneous detection of protein kinase A, protein kinase C, protein tyrosine kinase, and calmodulin-dependent protein kinase activities. Analytical Biochemistry 212: 106-110, 1993
• 5) UEHARA, Y.; H. FUKAZAWA, Y. MURAKAMI & S. MIZUNO: Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds. Biochem. Biophys. Res. Commun. 163: 803-809, 1989

Terms in the title (3)： 癌遺伝子 ,  Srcシグナル伝達 ,  阻害剤