Art

J-GLOBAL ID：200902126205856493   Reference number：01A0619473

Incadronate and Etidronate Accelerate Phosphate-Primed Mineralization of MC4 Cells via ERK1/2-Cbfal Signaling Pathway in a Ras-Independent Manner: Further Involvement of Mevalonate-Pathway Blocade for Incadronate.

インカドロナートおよびエチドロナートはラス癌遺伝子とは無関係にERK1/2-Cbfa1シグナル経路を経由してリン酸塩の初回抗原刺激を受けたMC4細胞の無機質化を加速する インカドロナートによるメバロン酸経路遮断の更なる関与

Author (7)： FUJITA T (Setunan Univ., Hirakata, JPN) ,  IZUMO N (Setunan Univ., Hirakata, JPN) ,  FUKUYAMA R (Setunan Univ., Hirakata, JPN) ,  MEGURO T (Setunan Univ., Hirakata, JPN) ,  YASUTOMI C (Setunan Univ., Hirakata, JPN) ,  NAKAMUTA H (Setunan Univ., Hirakata, JPN) ,  KOIDA M (Setunan Univ., Hirakata, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 86  Issue： 1  Page： 86-96  Publication year： May. 01, 2001 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *drug for treatment of bone disease ,...
Semi thesaurus term： *cellular signal transduction ,...

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JST classification (1)： Drugs acting on metabolism in general  (GW13010F)

Substance index (4)： Etidronate ,  Statine ,  Mevalonic Acid ,  Incadronate

Reference (42)：

• 1 Russell RG, Rogers MJ, Frith JC, Luckman SP, Coxon FP, Benford HL, Croucher PI, Shipman C and Fleisch HA: The pharmacology of bisphosphonates and new insights into their mechanisms of action. J Bone Miner Res 14, Suppl 2, 53 - 65 (1999)
• 2 Amin D, Cornell SA, Gustafson SK, Needle SJ, Ullrich JW, Bilder GE and Perrone MH: Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis. J Lipid Res 33, 1657 - 1663 (1992)
• 3 Luckman SP, Hughes DE, Coxon FP, Graham R, Russell RG and Rogers MJ: Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 13, 581 - 589 (1998)
• 4 Luckman SP, Coxon FP, Ebetino FH, Russell RG and Rogers MJ: Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages. J Bone Miner Res 13, 1668 - 1678 (1998)
• 5 Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russel RG, Rodan GA and Reszka AA: Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci USA 96, 133 - 138 (1999)

Terms in the title (14)： インカドロナート ,  エチドロナート ,  ラス ,  癌遺伝子 ,  ERK1 ,  Cbfa1 ,  シグナル経路 ,  リン酸塩 ,  抗原刺激 ,  細胞 ,  無機質化 ,  加速 ,  メバロン酸経路 ,  遮断