Art

J-GLOBAL ID：200902127464159012   Reference number：95A0733869

Synthesis and Biological Evaluation of 5-Fluoro-2′-deoxyuridine Phosphoramidate Analogs.

5-フルオロ-2′-デオキシウリジンホスホロアミダート類似体の合成と生物学的評価

Author (3)： FRIES K M (Univ. Rochester, New York) ,  JOSWIG C (Univ. Rochester, New York) ,  BORCH R F (Univ. Rochester, New York)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 38  Issue： 14  Page： 2672-2680  Publication year： Jul. 07, 1995 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： cytotoxicity ,...
Semi thesaurus term： floxuridine ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (38)： N-Methyl-2-bromoethanamine ,  2-Chloro-N-methylethanamine ,  N-Methyl-2-iodoethanamine ,  2,2-Dimethyl-1,3-dioxolane-4-ethanol ,  3′-O-(tert-Butyldimethylsilyl)-5-fluoro-2′-deoxyuridine ,  2′-Deoxy-3′-O-(tert-butyldimethylsilyl)uridine ,  N-Methyl-N-(2-bromoethyl)amidochloridophosphoric acid 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N-Methyl-N-(2-chloroethyl)amidochloridophosphoric acid 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N-Methyl-N-(2-iodoethyl)amidochloridophosphoric acid 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N,N-Bis(2-bromoethyl)amidochloridophosphoric acid 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  Chloromorpholinophosphinic acid 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N-Methyl-N-(2-bromoethyl)amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N-Methyl-N-(2-chloroethyl)amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N-Methyl-N-(2-iodoethyl)amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N-Methyl-N-[2-(tosyloxy)ethyl]amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  Morpholinophosphonic acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N-Methyl-N-(2-bromoethyl)amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-(2-chloroethyl)amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-(2-iodoethyl)amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-[2-(tosyloxy)ethyl]amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  Morpholinophosphonic acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-(2-bromoethyl)amidophosphoric acid 5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-(2-chloroethyl)amidophosphoric acid 5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-(2-iodoethyl)amidophosphoric acid 5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-[2-(tosyloxy)ethyl]amidophosphoric acid 5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  Morpholinophosphonic acid 5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  Piperidinophosphonic acid 5-fluoro-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N,N-Bis(2-bromoethyl)amidophosphoric acid 3′-O-(tert-butyldimethylsilyl)-5-fluoro-2′-deoxy-5′-uridyl 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl ester ,  N-Methyl-N-(2-bromoethyl)amidophosphoric acid 2′-deoxy-5′-uridyl 2-[2,2-dimethyl-1,3-dioxolan-4-yl]ethyl ester ,  N-Methyl-N-(2-bromoethyl)amidophosphoric acid 5-methyl-2′-deoxy-5′-uridyl 2-[2,2-dimethyl-1,3-dioxolan-4-yl]ethyl ester ,  N-Methyl-N-(2-bromoethyl)amidophosphoric acid 2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-(2-bromoethyl)amidophosphoric acid 5-methyl-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N-Methyl-N-(2-iodoethyl)amidophosphoric acid 2′-deoxy-5′-uridyl 2-[2,2-dimethyl-1,3-dioxolan-4-yl]ethyl ester ,  N-Methyl-N-(2-iodoethyl)amidophosphoric acid 2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N,N-Bis(2-bromoethyl)amidophosphoric acid 2′-deoxy-5′-uridyl 2-[2,2-dimethyl-1,3-dioxolan-4-yl]ethyl ester ,  N,N-Bis(2-bromoethyl)amidophosphoric acid 5-methyl-2′-deoxy-5′-uridyl 2-[2,2-dimethyl-1,3-dioxolan-4-yl]ethyl ester ,  N,N-Bis(2-bromoethyl)amidophosphoric acid 2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester ,  N,N-Bis(2-bromoethyl)amidophosphoric acid 5-methyl-2′-deoxy-5′-uridyl 2-[(4,4,6-trimethyltetrahydro-2H-1,3-oxazin)-2-yl]ethyl ester

Terms in the title (3)： 5-フルオロ-2′-デオキシウリジン ,  類似体 ,  生物学的評価