Art

J-GLOBAL ID：200902128222850337   Reference number：02A0956070

Chemical Modification of Reveromycin A and Its Biological Activities.

レベロマイシンAの化学修飾及びその生物活性

Author (6)： SHIMIZU T (RIKEN, Saitama, JPN) ,  USUI T (RIKEN, Saitama, JPN) ,  MACHIDA K (RIKEN, Saitama, JPN) ,  FURUYA K (RIKEN, Saitama, JPN) ,  OSADA H (RIKEN, Saitama, JPN) ,  NAKATA T (RIKEN, Saitama, JPN)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 12  Issue： 23  Page： 3363-3366  Publication year： Dec. 02, 2002 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *antibiotics ,...

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JST classification (2)： Synthesis of antibiotics  (GX04000Z) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (20)： Reveromycin A ,  Reveromycin B ,  Reveromycin C ,  Reveromycin D ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-methoxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-hydroxy-1,3-pentadienyl]-9-butyl-9-(4-hydroxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-acetoxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-hydroxy-1,3-pentadienyl]-9-butyl-9-(4-hydroxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-(tert-butyldimethylsiloxy)-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-hydroxy-1,3-pentadienyl]-9-butyl-9-(4-hydroxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-methoxy-1,3-pentadienyl]-9-butyl-9-(4-methoxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid methyl ester ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-hydroxy-1,3-pentadienyl]-9-butyl-9-(4-methoxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid methyl ester ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-methoxy-1,3-pentadienyl]-9-butyl-9-(4-hydroxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid methyl ester ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-methoxy-1,3-pentadienyl]-9-butyl-9-(4-methoxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-hydroxy-1,3-pentadienyl]-9-butyl-9-(4-hydroxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid methyl ester ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-methoxy-1,3-pentadienyl]-9-butyl-9-(4-hydroxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-hydroxy-1,3-pentadienyl]-9-butyl-9-(4-methoxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid ,  (4S,5S)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-(3-methyl-5-oxo-5-hydroxypentyl)-9-butyl-9-(4-hydroxy-1,4-dioxobutoxy)-1,7-dioxaspiro[5.5]undecane-2-yl]decanoic acid ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-hydroxy-1,3-pentadienyl]-9-butyl-9-hydroxy-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid ,  (2E,4S,5R,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,5S)-2α-butyl-2-[(1S,2E,4E)-1,6-dihydroxy-4-methyl-6-oxo-2,4-hexadienyl]-8β-methyl-1,6-dioxaspiro[4.5]decane-7α-yl]-2,6,8-decatrienoic acid ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-(tert-butyldimethylsiloxy)-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-methoxy-1,3-pentadienyl]-9-butyl-9-hydroxy-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid methyl ester ,  (2E,4S,5S,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,3S,6S,8S,9R)-3-methyl-8-[(1E,3E)-3-methyl-5-oxo-5-hydroxy-1,3-pentadienyl]-9-butyl-9-methoxy-1,7-dioxaspiro[5.5]undecane-2-yl]-2,6,8-decatrienoic acid ,  (2E,4S,5R,6E,8E)-4,8-Dimethyl-5-hydroxy-10-[(2R,5S)-2α-butyl-2-[(1S,2E,4E)-1-methoxy-4-methyl-6-oxo-6-hydroxy-2,4-hexadienyl]-8β-methyl-1,6-dioxaspiro[4.5]decane-7α-yl]-2,6,8-decatrienoic acid

Terms in the title (3)： レベロマイシンA ,  化学修飾 ,  生物活性