Art

J-GLOBAL ID：200902128412865845   Reference number：99A0956473

Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4.

ウォルトマンニンによるCTLA4発現増加 リソソームによるCTLA4選別性の関与

Author (3)： OKI S (National Children’s Medical Res. Center, Tokyo, JPN) ,  KOHSAKA T (National Children’s Medical Res. Center, Tokyo, JPN) ,  AZUMA M (National Children’s Medical Res. Center, Tokyo, JPN)
Material： International Immunology  (Int Immunol)
Volume： 11  Issue： 9  Page： 1563-1571  Publication year： Sep. 1999 
JST Material Number： W0116A  ISSN： 0953-8178  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *protein ,...
Semi thesaurus term： T lymphocyte ,...

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JST classification (1)： Immunological reaction in general  (ED03010T)

Substance index (2)： Wortmannin ,  Monensin

Reference (50)：

• LINSLEY, P. S. T-cell antigen CD28 mediates adhesion with Bcells by interacting with activation antigen B7/BB-1. Proc. Natl Acad. Sci. USA. 1990, 87, 5031
• AZUMA, M. B70 antigen is a second ligand for CTLA-4 and CD28. Nature. 1993, 366, 76
• KRUMMEL, M. F. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 1995, 182, 459
• KRUMMEL, M. F. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 1996, 183, 2533
• WALUNAS, T. L. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994, 1, 405

Terms in the title (5)： ウォルトマンニン ,  CTLA4 ,  発現 ,  リソソーム ,  選別