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J-GLOBAL ID:200902129421114220   Reference number:01A0838444

Renin-Angiotensin System is Involved in the Mechanism of Increased Serum Asymmetric Dimethylarginine in Essential Hypertension.

高血圧症における血清中不斉ジメチルアルギニン濃度上昇機序へのレニン-アンギオテンシン系の関与
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Volume: 65  Issue:Page: 775-778  Publication year: Sep. 2001 
JST Material Number: F0908A  ISSN: 0047-1828  CODEN: NJUGA  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: ENGLISH (EN)
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Cardiovascular system diseases 
Reference (22):
  • 1. Furchgot RF, Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-376
  • 2. Cooke JP, Dzau VJ: Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases. Circulation 1997; 96: 379-382
  • 3. Takemoto M, Egashira K, Usui M, Numaguchi K, Tomita H, Tsutsui H, et al: Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats. J Clin Invest 1997; 99: 278-287
  • 4. Boeger RH, Bode-Boeger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, et al: Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction: Its role in hypercholesterolemia. Circulation 1998; 98: 1842-1847
  • 5. Miyazaki H, Matsuoka H, Cooke JP, Usui M, Ueda S, Okuda S, et al: Endogenous nitric oxide synthase inhibitor: A novel marker of atherosclerosis. Circulation 1999; 99: 1141-1146
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