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J-GLOBAL ID：200902130469753088   Reference number：01A0706258

Hypophosphorylation of Topoisomerase IIα in Etoposide (VP-16)-resistant Human Carcinoma Cell Lines Associated with Carboxy-terminal Truncation.

C末端切断に関係したエトポシド(VP-16)耐性ヒト癌細胞株におけるトポイソメラーゼIIαのりん酸化の低下

Author (5)： MATSUMOTO Y (Kagawa Medical Univ., Kagawa) ,  TAKANO H (NIH, MD, USA) ,  KUNISHIO K (Kagawa Medical Univ., Kagawa) ,  NAGAO S (Kagawa Medical Univ., Kagawa) ,  FOJO T (NIH, MD, USA)
Material： Japanese Journal of Cancer Research  (Proceedings. Annual Meeting of the Japanese Cancer Association)
Volume： 92  Issue： 7  Page： 799-805  Publication year： Jul. 31, 2001 
JST Material Number： F0633A  ISSN： 0910-5050  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antitumor drug ,...
Semi thesaurus term： T47D細胞

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JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Molecular genetics in general  (EC02010J)

Substance index (1)： Etoposide

Reference (22)：

• MATSUMOTO, Y. Cellular adaptation to drug exposure: evolution of the drug-resistant phenotype. Cancer Res. 1997, 57, 5086-5092
• TAKANO, H. Increased phosphorylation of DNA topoisomerase II in etoposide resistant mutants of human cancer KB cells. Cancer Res. 1991, 51, 3951-3957
• CAMPAIN, J. A. A novel mutant topoisomerase IIα present in VP-16-resistant human melanoma cell lines has deletion of alanine 429. Biochemistry. 1994, 33, 11327-11332
• CRENSHAW, D. W. Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. J. Biol. Chem. 1993, 268, 21335-21343
• WELLS, N. J. Serine 1524 is a major site of phosphorylation on human topoisomerase IIα protein in vivo and is a substrate for casein kinase II in vitro. J. Biol. Chem. 1994, 270, 29746-29751

Terms in the title (8)： C末端 ,  エトポシド ,  VP-16 ,  耐性 ,  ヒト ,  癌細胞株 ,  トポイソメラーゼIIα ,  りん酸化