Art

J-GLOBAL ID：200902131003612510   Reference number：94A0185782

Synthesis and Biological Evaluation of 5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: Novel Dual 5-Lipoxygenase and Cyclooxygenase Inhibitors with Antiinflammatory Activity.

5-[[3,5-ビス(1,1-ジメチルエチル)-4-ヒドロキシフェニル]メチレン]オキサゾール-チアゾールおよび-イミダゾールの合成と生物学的評価 5-リポキシゲナーゼとシクロオキシゲナーゼを同時に阻害する新規抗炎症薬

Author (9)： UNANGST P C (Parke-Davis Pharmaceutical Research, Michigan) ,  CONNOR D T (Parke-Davis Pharmaceutical Research, Michigan) ,  CETENKO W A (Parke-Davis Pharmaceutical Research, Michigan) ,  SORENSON R J (Parke-Davis Pharmaceutical Research, Michigan) ,  KOSTLAN C R (Parke-Davis Pharmaceutical Research, Michigan) ,  SIRCAR J C (Parke-Davis Pharmaceutical Research, Michigan) ,  WRIGHT C D (Parke-Davis Pharmaceutical Research, Michigan) ,  SCHRIER D J (Parke-Davis Pharmaceutical Research, Michigan) ,  DYER R D (Parke-Davis Pharmaceutical Research, Michigan)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 37  Issue： 2  Page： 322-328  Publication year： Jan. 21, 1994 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： Mycobacterium ,...

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JST classification (1)： Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (26)： CI-987 ,  2-Mercapto-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-Amino-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-Mercapto-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)oxazol-4(5H)-one ,  2-Hydroxy-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1-methyl-1H-imidazol-4(5H)-one ,  2-Mercapto-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1-methyl-1H-imidazol-4(5H)-one ,  2-(Methylthio)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-(Methylamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-(Dimethylamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-(Hydroxyamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-[Hydroxy(methyl)amino]-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  PD-138387 ,  2-[Methoxy(methyl)amino]-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-(Cyanoamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-(Amidinoamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-[(Dimethylamino)(imino)methylamino]-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-[[2-(Dimethylamino)ethyl]amino]-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one ,  2-(Cyanoamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)oxazol-4(5H)-one ,  2-(Amidinoamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)oxazol-4(5H)-one ,  4-Mercapto-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)-3,4-dihydro-2H-pyrrol-2-one ,  2-(Cyanoamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1-methyl-1H-imidazol-4(5H)-one ,  2-(Amidinoamino)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-1-methyl-1H-imidazol-4(5H)-one ,  2-Hydroxy-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)oxazol-4(5H)-one ,  KME-4 ,  BF-389 ,  Sodium meclofenamate

Terms in the title (10)： ビス ,  メチレン ,  オキサゾール ,  チアゾール ,  イミダゾール ,  生物学的評価 ,  5-リポキシゲナーゼ ,  シクロオキシゲナーゼ ,  阻害 ,  抗炎症薬