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J-GLOBAL ID：200902131059407022   Reference number：98A0696248

Sensitivity to Ionizing Radiation in Saos-2 Cells Transfected with Mutant p53 Genes Depends on the Mutation Position.

p53遺伝子変異体を導入したSaos-2細胞の電離放射線に対する感受性は変異位置に依存する

Author (4)： OKAICHI K (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  WANG L-H (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  IHARA M (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  OKUMURA Y (Nagasaki Univ. School of Medicine, Nagasaki, JPN)
Material： Journal of Radiation Research  (J Radiat Res)
Volume： 39  Issue： 2  Page： 111-118  Publication year： Jun. 1998 
JST Material Number： F0337A  ISSN： 0449-3060  CODEN： JRARAX  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tumor suppressor gene ,...

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JST classification (2)： Influence on cellular levels  (EK02030D) ,  Carcinogenic mechanisms and factors  (GE02020C)

Reference (24)：

• 1) Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C. C. (1991) p53 mutations in human cancers. Science 253: 49-53.
• 2) Levine, A. J., Momand, J. and Finlay, C. A. (1991) The p53 tumor suppresser gene. Nature 351: 453-456.
• 3) Finlay, C. A., Hinds, P. W. and Levine, A. J. (1989) The p53 proto-oncogene can act as a suppressor of transformation. Cell 57: 1083-1093.
• 4) Baker, S. J., Markowitz, S., Fearon, E. R., Willson, J. K. and Vogelstein, B. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249: 912-915.
• 5) Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. and Craig, R. W. (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51: 6304-6311.

Terms in the title (6)： p53遺伝子 ,  変異体 ,  Saos-2細胞 ,  電離放射線 ,  感受性 ,  変異