Art

J-GLOBAL ID：200902131148594995   Reference number：93A0607676

Antihypertensive activity of the angiotensin converting enzyme inhibitor quinapril HCl:(S)-2-[(S)-N-[(S)-1-ethoxycarbonyl-3-phenylpropyl)alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid monohydrochloride in various hypertensive animal models.

各種高血圧モデルにおける新規アンジオテンシン変換酵素阻害薬キナプリルの降圧作用

Author (4)： YAOKA OSAMU (吉富製薬 中研) ,  AOKI KAZUMI (吉富製薬 中研) ,  NAKAJIMA TOORU (吉富製薬 中研) ,  SETOGUCHI MICHIHIDE (吉富製薬 中研)
Material： 日本薬理学雑誌  (日本薬理学会西南部会抄録)
Volume： 102  Issue： 1  Page： 35-45  Publication year： Jul. 1993 
JST Material Number： G0740A  ISSN： 0015-5691  CODEN： NYKZA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： animal test ,...
Semi thesaurus term： キナプリル ,...

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JST classification (2)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (3)： Quinapril hydrochloride ,  Enalapril ,  Captopril

Reference (21)：

• 1) Heel, R.C., Brogden, R.N., Speight, T.M. and Avery, G.S.: Captopril: A preliminary review of its pharmacological properties and therapeutic efficacy. Drugs 20, 409 ?? 452 (1980)
• 2) Perry, R.S.: Enalapril maleate (MK-421, Reniten^®): an improved ACE inhibitor. Drugs of Todays 21, 31 ?? 40 (1985)
• 3) Stornello, M., Valvo, E.V. and Scapellato, L.: Hemodynamic, renal, and humoral effects of the calcium entry blocker nicardipine and converting enzyme inhibitor captopril in hypertensive type II diabetic patients with nephropathy. J. Cardiovasc. Pharmacol. 14, 851 ?? 855 (1989)
• 4) Swedberg, K.: Effects of enalapril on mortality in severe congestive heart failure. N. Engl. J. Med. 316 (23), 1429 ?? 1435 (1987)
• 5) Kaplan, H.R., Taylor, D.G., Olson, S.C. and Andrews, L.K.: Quinapril-A preclinical review of the pharmacology, pharmacokinetics, and toxicology. Angiology 40(2), 335 ?? 350 (1989)

Terms in the title (5)： 血圧 ,  モデル ,  アンジオテンシン変換酵素阻害薬 ,  キナプリル ,  降圧作用