Art

J-GLOBAL ID：200902131533312984   Reference number：98A0317275

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy.

高度の経口バイオアベイラビリティと臨床効果を持つ強力なHIVプロテアーゼ阻害剤,リトナビルの発見

Author (9)： KEMPF D J (Abbott Lab., Illinois) ,  SHAM H L (Abbott Lab., Illinois) ,  MARSH K C (Abbott Lab., Illinois) ,  KATI W M (Abbott Lab., Illinois) ,  RUIZ L (Abbott Lab., Illinois) ,  ZHAO C (Abbott Lab., Illinois) ,  FINO L (Abbott Lab., Illinois) ,  MOLLA A (Abbott Lab., Illinois) ,  NORBECK D W (Abbott Lab., Illinois)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 41  Issue： 4  Page： 602-617  Publication year： Feb. 12, 1998 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *tripeptide ,...
Semi thesaurus term： リトナビル ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=98A0317275&from=J-GLOBAL&jstjournalNo=D0102A") }}

JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Peptides  (CF10080G)

Substance index (30)： A-80987 ,  Ritonavir ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[[methyl(2-pyridinylmethyl)amino]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[(2-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[(5-methyl-3-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[(5-methyl-3-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[(5-methoxy-2-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[(5-methoxy-2-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[(5-methoxy-3-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[(5-methoxy-3-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[(5-amino-2-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[(5-amino-2-pyridinylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[(pyrazin-2-ylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[(6-methylpyrazin-2-ylmethoxy)carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[[methyl[(thiazol-4-yl)methyl]amino]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[[methyl[(2-methylthiazol-4-yl)methyl]amino]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[[(2-isopropyloxazol-4-yl)methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[[(2-isopropyloxazol-4-yl)methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[3-(2-isopropylthiazol-4-yl)propanoyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[[[2-(methoxymethyl)thiazol-4-yl]methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[[(2-ethylthiazol-4-yl)methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[[(2-ethylthiazol-4-yl)methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[[(5-tert-butylisoxazol-3-yl)methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[[(5-tert-butylisoxazol-3-yl)methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 3-pyridinylmethyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[[(2-pyridinyl)methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid (pyrimidin-5-yl)methyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[N-[[methyl(2-pyridinylmethyl)amino]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid (pyrimidin-5-yl)methyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-(5-thiazolylmethoxycarbonylamino)-5-phenylpentyl]-N^α-(2-pyridylmethoxycarbonyl)-L-valinamide ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[N-[[(2-pyridinyl)methoxy]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid (thiazol-5-yl)methyl ester ,  N-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[[[[methyl[(2-ethyl-4-thiazolyl)methyl]amino]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 5-thiazolylmethyl ester ,  N-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4-[[[[methyl[(2-ethyl-4-thiazolyl)methyl]amino]carbonyl]-L-valyl]amino]-5-phenylpentyl]carbamic acid 5-thiazolylmethyl ester

Terms in the title (6)： 高度 ,  経口バイオアベイラビリティ ,  臨床効果 ,  HIVプロテアーゼ阻害剤 ,  リトナビル ,  発見