Art

J-GLOBAL ID：200902132124592556   Reference number：94A0107328

Oleic acid-induced PaO₂ decrease model for primary screening of drugs for hypoxemia. Effects of tranexamic acid and procaterol hydrochloride on the decrease in PaO₂.

低酸素血症治療薬の一次スクリーニング系 トラネキサム酸および塩酸プロカテロールの効果

Author (2)： MORIUCHI HIROSHI (熊本大 薬) ,  YUIZONO TOMOKAZU (熊本大 薬)
Material： 日本薬理学雑誌  (日本薬理学会西南部会抄録)
Volume： 103  Issue： 1  Page： 27-36  Publication year： Jan. 1994 
JST Material Number： G0740A  ISSN： 0015-5691  CODEN： NYKZA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： animal test ,...
Semi thesaurus term： hypoxemia acidosis ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=94A0107328&from=J-GLOBAL&jstjournalNo=G0740A") }}

JST classification (3)： Basic research of drugs acting on blood and body fluid  (GW14010M) ,  Basic research of drugs acting on respiration and respiratory system  (GW08010J) ,  Basic medicine on respiratory system  (GI01020H)

Substance index (2)： Tranexamic Acid ,  Procaterol

Reference (31)：

• 1) Derks, C.M. and Jacobovitz-Derks, D.: Embolic pneumopathy induced by oleic acid. Am. J. Pathol. 87, 143 ?? 158 (1977)
• 2) Ashbaugh, D.G. and Uzawa, T.: Respiratory and hemodynamic changes after injection of free fatty acids. J. Surg. Res. 18, 417 ?? 426 (1968)
• 3) Dickey, B.F., Thrall, R.S., McCormick, J.R. and Ward, P.A.: Oleic acid-induced lung injury in the rat. Am. J. Pathol. 103, 376 ?? 383 (1981)
• 4) Montaner, J.S.G., Tsang, J., Evans, K.G., Mullen, J.B.M., Burns, A.R., Walker, D.C., Wiggs, B. and Hogg, J.C.: Alveolar epithelial damage; A critical difference between high pressure and oleic acid-induced low pressure pulmonary edema. J. Clin. Invest. 77, 1786 ?? 1796 (1986)
• 5) Ali, J. and Wood, L.D.H.: Factors affecting perfusion distribution in canine oleic acid pulmonary edema. J. Appl. Physiol. 60, 1498 ?? 1503 (1986)

Terms in the title (5)： 低酸素血症 ,  治療薬 ,  スクリーニング ,  トラネキサム酸 ,  塩酸プロカテロール