Art

J-GLOBAL ID：200902132168504360   Reference number：00A0077711

Comparative toxicokinetic study of rubber antioxidants, 2-mercaptobenzimidazole and 2-mercaptomethylbenzimidazole, by single oral administration in rats.

ラットにおける単独経口投与によるゴム酸化防止剤,2-メルカプトベンゾイミダゾール及び2-メルカプトメチルベンゾイミダゾールの比較毒物動力学研究

Author (5)： SAKEMI K (National Inst. Health Sci., Tokyo, JPN) ,  USAMI M (National Inst. Health Sci., Tokyo, JPN) ,  MITSUNAGA K (National Inst. Health Sci., Tokyo, JPN) ,  OHNO Y (National Inst. Health Sci., Tokyo, JPN) ,  TSUDA M (National Inst. Health Sci., Tokyo, JPN)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 24  Issue： 5  Page： 399-405  Publication year： Dec. 1999 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *acute toxicity ,...

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JST classification (1)： Toxicity of organic compounds  (GZ02030Y)

Substance index (2)： 1H-Benzimidazole-2-thiol ,  1H-Benzimidazole-2-methanethiol

Reference (9)：

• Dahlem, A.M., Allerheilingen, S.R. and Vodicnik, M.J. (1995): Concomitant toxicokinetics: Techniques for and interpretation of exposure data obtained during the conduct of toxicology studies. Toxicol. Pathol. 23, 170-178.
• El Dareer, S.M., Kalin, J.R., Tillery, K.F. and Hill, D.L. (1984): Disposition of 2-mercaptobenzimidazole in rats dosed orally or intravenously. J. Toxicol. Environ. Health, 14,595-604.
• Gaworski, C.L., Aranyi, C., Vana, S., Rajendran, N., Abdo, K., Levine, B.S. and Hall III, A. (1991): Prechronic inhalation studies of 2-mercaptobenz-imidazole (2-MBI) in F344/N rats. Fundament. Appl. Toxicol., 16, 161-171.
• International Conference on Harmonization (1994): Note for guidance on toxicokinetics: The assessment of systemic exposure in toxicity studies.
• Isama, K., Momma, J., Kaniwa, M. and Nakamura, A. (1998): Structure-activity relationships for skin sensitization potential of 2-mercaptobenzimidazole and its methyl derivatives. Environ. Dermatol., 5,26-33.

Terms in the title (7)： ラット ,  経口投与 ,  ゴム ,  酸化防止剤 ,  2-メルカプトベンゾイミダゾール ,  毒物動力学 ,  研究