Art

J-GLOBAL ID：200902132868655165   Reference number：01A1010681

L-2,5-Dihydrophenylalanine, an Inducer of Cathepsin-dependent Apoptosis in Human Promyelocytic Leukemia Cells (HL-60).

ヒト前骨髄球白血病細胞(HL-60)のカテプシン依存アポトーシスの誘導剤,L-2,5-ジヒドロフェニルアラニン

Author (5)： KISO T (Osaka City Univ., Osaka, JPN) ,  USUKI Y (Osaka City Univ., Osaka, JPN) ,  PING X (Osaka City Univ., Osaka, JPN) ,  FUJITA K (Osaka City Univ., Osaka, JPN) ,  TANIGUCHI M (Osaka City Univ., Osaka, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 54  Issue： 10  Page： 810-817  Publication year： Oct. 25, 2001 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *amino acid ,...
Semi thesaurus term： cathepsin B ,...

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JST classification (2)： Antibiotics in general  (GX01000E) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： DHPA

Reference (42)：

• 1) YAMASHITA, T; N. MIYAIRI, K. KUNUGITA, K. SHIMIZU & H. SAKAI: L-1,4-Cyclohexadiene-l-alanine, an antagonist of phenylalanine from Streptomyces. J. Antibiotics 23: 537-541, 1970
• 2) GENGHOF, D. S.: 2,5-Dihydrophenylalanine as an inhibitor of microbial growth. Can. J. Microbiol. 16: 545-547, 1970
• 3) OKABAYASHI, K.; H. MORISHIMA, M. HAMADA, T. TAKEUCHI & H. UMEZAWA: A tryptophan hydroxylase inhibitor produced by a Streptomycete: 2,5-dihydro-Lphenylalanine. J. Antibiotics 30: 675-677, 1977
• 4) WATANABE, Y.; M. FUJIWARA & O. HAYAISHI: 2,5-Dihydro-L-phenylalanine: a competitive inhibitor of indoleamine 2,3-dioxygenase. Biochem. Biophys. Res. Commun. 85: 273-279, 1978
• 5) MILLER, R. J. & S. J. BENKOVIC: L-[2, 5-H₂]Phenylalanine, an alternate substrate for rat liver phenylalanine hydroxylase. Biochemistry 27: 3658-3663, 1988

Terms in the title (5)： ヒト ,  白血病細胞 ,  カテプシン ,  アポトーシス ,  誘導