Art

J-GLOBAL ID：200902133249272355   Reference number：02A0952988

Comparative Analysis of In Vitro and In Vivo Pharmacokinetic Parameters Related to Individual Variability of GTS-21 in Canine.

イヌでのGTS-21の個体差に関与したin vitroとin vivo薬物動力学的パラメーターの比較分析

Author (6)： AZUMA R (Taiho Pharmaceutical Co., Ltd., Tokushima, JPN) ,  KOMURO M (Taiho Pharmaceutical Co., Ltd., Tokushima, JPN) ,  KAWAGUCHI Y (Taiho Pharmaceutical Co., Ltd., Tokushima, JPN) ,  OKUDAIRA K (Toho Univ., Chiba, JPN) ,  HAYASHI M (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  KIWADA H (Univ. Tokushima, Tokushima, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 17  Issue： 1  Page： 75-82  Publication year： Mar. 2002 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： dog ,...
Semi thesaurus term： bridged compound ,...

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JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (7)： α-Naphthoflavone ,  Furafylline ,  Quinidine ,  Quinine ,  Troleandomycin ,  GTS-21 ,  4-OH-GTS-21

Reference (26)：

• DANCKWERTS, M. P. Pharmacokinetic evaluation in dogs of theophylline in a novel zero-order release core-in-cup tablet. Biopharm. Drug Dispos. 1998, 19, 517-522
• KHALED, K. A. In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs. Int. J. Pharm. 2001, 222, 1-6
• PAULSON, S. K. Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib. Drug Metab. Dispos. 1999, 27, 1133-1142
• KEM, W. R. The brain α7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). Behav. Brain Res. 2000, 113, 169-181
• ADAMS, C. E. Inhibition of nitric oxide synthase prevents α7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus. Brain Res. 2000, 877, 235-244

Terms in the title (6)： イヌ ,  GTS-21 ,  個体差 ,  薬物動力学 ,  パラメーター ,  比較分析